Model Details

Patient Information for Model: BCM-15100

Patient Information
Clinical Timeline

Color Keys:
 
 Positive
 
 Negative
 
 N/A

Clinical Information at Collection
Clinical Biomarkers/Mutations at Collection
Pathology Information at Collection

Model Information for Model: BCM-15100

Model Details - Initial Implantation of Patient Tissue
Biomarkers & Mutations
Model Details - Acceptable Conditions for Passaging
Mutations (Cancer Gene Census List)

The number of models in this collection with mutations in the listed gene;
may include models that are not publicly available for distribution.
The number of models in this collection with mutations at the listed site;
may include models that are not publicly available for distribution.
GeneChrStartEndRefAltcDNA ChangeCodon ChangeProtein ChangeTVAF Gene Mutation Freq. Site Mutation Freq.Most Severe EffectAll EffectsMutation ImpactTranscript IDClinVar Clinical SignificanceCOSMIC IDgnomAD Non-Cancer AFdbSNP IDGene Mutation Freq.Site Mutation Freq.Transcript IDClinVar Clinical SignificanceCOSMIC IDdbSNP ID
AKAP9chr79202286492022864AAAACc.4004_4006dupaaa/aAACaap.K1335_L1336insQ0.9635035In-frame InsertionIn-frame InsertionMODERATEENST00000356239.8

COSV62337888
rs10644111
5035ENST00000356239.8COSV62337888rs10644111
ARID1Bchr6156778268156778268CCCAGCAGc.606_611dup-/CAGCAGp.Q213_Q214dup0.914373In-frame InsertionIn-frame InsertionMODERATEENST00000636930.2

COSV51647062

373ENST00000636930.2COSV51647062
ATRXchrX7768247177682471CGc.2785G>CGag/Cagp.E929Q0.9855956Missense VariantMissense VariantMODERATEENST00000373344.10
Benign

rs3088074
5956ENST00000373344.10Benignrs3088074
CHD4chr1265998986599898GAc.1357C>TCgg/Tggp.R453W0.44151Missense VariantMissense VariantMODERATEENST00000544040.7


rs1948560535
51ENST00000544040.7rs1948560535
CIITAchr161090907010909070AGc.2702A>GcAg/cGgp.Q901R0.9778584Missense VariantMissense VariantMODERATEENST00000618327.4
Benign

0.983235000000rs7197779
8584ENST00000618327.4Benignrs7197779
CLIP1chr12122279123122279123CAc.3670G>TGca/Tcap.A1224S0.742Missense VariantMissense VariantMODERATEENST00000620786.4
Likely_benign

0.005091810000rs17881033
42ENST00000620786.4Likely_benignrs17881033
COL1A1chr175019797850197978GCc.613C>GCct/Gctp.P205A0.634112Missense VariantMissense VariantMODERATEENST00000225964.10
Conflicting_interpretations_of_pathogenicity

0.003288860000rs72667032
112ENST00000225964.10Conflicting_interpretations_of_pathogenicityrs72667032
CREB3L2chr7137928167137928170CTGGCc.299_301delaCCAgt/agtp.T100del0.5344949In-frame DeletionIn-frame DeletionMODERATEENST00000330387.11

COSV57791862
rs3217268
4949ENST00000330387.11COSV57791862rs3217268
CREBBPchr1637291143729114TCc.5933A>GaAc/aGcp.N1978S0.34871Missense VariantMissense VariantMODERATEENST00000262367.10
Benign
COSV52116951
0.005018440000rs112906840
71ENST00000262367.10BenignCOSV52116951rs112906840
CYSLTR2chr134870696548706965TGc.148T>GTtc/Gtcp.F50V0.48971Missense VariantMissense VariantMODERATEENST00000282018.4
Likely_benign

0.004790270000rs143085034
71ENST00000282018.4Likely_benignrs143085034
CYSLTR2chr134870764948707649TAc.832T>ATta/Atap.L278I0.46671Missense VariantMissense VariantMODERATEENST00000282018.4
Likely_benign

0.004793390000rs138722135
71ENST00000282018.4Likely_benignrs138722135
CYSLTR2chr134870712548707125AGc.308A>GaAt/aGtp.N103S0.43171Missense VariantMissense VariantMODERATEENST00000282018.4
Likely_benign

0.005091080000rs116932219
71ENST00000282018.4Likely_benignrs116932219
EP300chr224111752541117525CTc.433C>TCag/Tagp.Q145*0.417221Nonsense MutationNonsense MutationHIGHENST00000263253.9

COSV54331679

221ENST00000263253.9COSV54331679
ERCC2chr194535166145351661TGc.2251A>CAag/Cagp.K751Q0.9544846Missense VariantMissense VariantMODERATEENST00000391945.10
Benign/Likely_benign
COSV67266431
0.322955000000rs13181
4846ENST00000391945.10Benign/Likely_benignCOSV67266431rs13181
ESR1chr6152098788152098788ACc.1610A>CtAt/tCtp.Y537S0.97103Missense VariantMissense VariantMODERATEENST00000440973.5

COSV52783938

103ENST00000440973.5COSV52783938
CNV


Histology Information for Model: BCM-15100
There are no histology images for this model.













Metastasis Information for Model: BCM-15100
 
Patient
PDX
Abdomen
Abdominal cavity
Adrenal Gland
Anterosuperior mediastinum
Ascites
Axillary Lymph Node
Bone
Brain
CTC
Chest
Chest wall
Contralateral Breast
Fallopian tubes
Head
Hilar Node
Hip
Kidney
Leg bone
Leptomeninges
Liver
Lung
Lymph Node
Mediastinum
Metastasis Pleura
Neck
None
Other
Ovary
Pancreas
Paratracheal adenopathy
Pericardium
Peritoneal cavity
Peritoneum
Pleura
Pleural cavity
Pleural effusion
Posterior cervical nodes
Pulmonary
Retrocrural Lymph Node
SVC node
Sacral Spine
Skin
Spine
Spleen
Thymus

Patient Treatment Information for Model: BCM-15100

Event IdTreatmentTreatment SettingAge at StartAge at EndDurationReason Stopped
15Cyclophosphamide,DocetaxelAdjuvant38.1138.3691 daysTreatment Completed
20Radiation Therapy (RT)Adjuvant38.3638.4429 daysTreatment Completed
25TamoxifenAdjuvant38.5339.67416 daysDisease Progression
35Leuprolide,OtherMetastatic39.6639.7533 days
40Letrozole,OtherMetastatic39.7542.12865 daysSide Effects
45OophorectomyMetastatic39.8139.81Unknown
55TamoxifenMetastatic42.1242.134 daysDisease Progression
60Other,PaclitaxelMetastatic42.1742.4188 days
70Fulvestrant,OtherMetastatic42.4343.29314 daysDisease Progression
85Capecitabine,OtherMetastatic43.344.04270 daysDisease Progression
100Fulvestrant,PalbociclibMetastatic44.1644.65179 daysDisease Progression
120DoxorubicinMetastatic44.7745.37219 daysDisease Progression
130EribulinMetastatic45.4845.780 daysDisease Progression
145CarboplatinMetastatic45.745.7311 daysSide Effects
150Radiation Therapy (RT)Metastatic45.820.0UnknownTreatment Completed














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