PDX Portal

Model Details

Patient Information for Model: BCM-15057

Patient Information

Clinical Timeline

Color Keys:

Positive

Negative

N/A

Clinical Information at Collection

Clinical Biomarkers/Mutations at Collection

Pathology Information at Collection

Model Information for Model: BCM-15057

Model Details - Initial Implantation of Patient Tissue

Biomarkers & Mutations

Model Details - Acceptable Conditions for Passaging

Mutations (Cancer Gene Census List)

GeneFilter by Gene	ChrFilter by Chr	Start	End	Ref	Alt	cDNA Change	Codon Change	Protein Change	TVAF	Gene Mutation Freq.	Site Mutation Freq.	Most Severe Effect	All Effects	Mutation Impact	Transcript ID	ClinVar Clinical Significance	COSMIC ID	gnomAD Non-Cancer AF	dbSNP ID	Gene Mutation Freq.	Site Mutation Freq.	Transcript ID	ClinVar Clinical Significance	COSMIC ID	dbSNP ID
ACSL3	chr2	222908920	222908920	G	A	c.148G>A	Gaa/Aaa	p.E50K	0.457	2	1	Missense Variant	Missense Variant	MODERATE	ENST00000357430.8					2	1	ENST00000357430.8
AKAP9	chr7	92022864	92022864	A	AAAC	c.4004_4006dup	aaa/aAACaa	p.K1335_L1336insQ	0.974	50	35	In-frame Insertion	In-frame Insertion	MODERATE	ENST00000356239.8		COSV62337888		rs10644111	50	35	ENST00000356239.8		COSV62337888	rs10644111
ARHGEF10	chr8	1956882	1956882	C	A	c.3654C>A	gaC/gaA	p.D1218E	0.968	10	1	Missense Variant	Missense Variant	MODERATE	ENST00000349830.8			0.000877889000	rs139515492	10	1	ENST00000349830.8			rs139515492
BARD1	chr2	214767531	214767532	CA	TG	c.1518_1519inv	caTGtg/caCAtg	p.V507M	0.503	34	24	Missense Variant	Missense Variant	MODERATE	ENST00000260947.9		COSV105837301		rs386654966	34	24	ENST00000260947.9		COSV105837301	rs386654966
BRCA2	chr13	32394781	32394781	C	G	c.9349C>G	Cat/Gat	p.H3117D	0.04	21	1	Missense Variant	Missense Variant	MODERATE	ENST00000380152.7					21	1	ENST00000380152.7
CEBPA	chr19	33301825	33301825	G	GGCGGGT	c.584_589dup	ccg/cACCCGCcg	p.H195_P196dup	0.449	9	6	In-frame Insertion	In-frame Insertion	MODERATE	ENST00000498907.3		COSV57196906			9	6	ENST00000498907.3		COSV57196906
CIITA	chr16	10907647	10907647	G	A	c.2158G>A	Gcc/Acc	p.A720T	0.968	85	1	Missense Variant	Missense Variant	MODERATE	ENST00000618327.4			0.000008444590	rs755306140	85	1	ENST00000618327.4			rs755306140
CIITA	chr16	10909070	10909070	A	G	c.2702A>G	cAg/cGg	p.Q901R	0.984	85	84	Missense Variant	Missense Variant	MODERATE	ENST00000618327.4	Benign		0.983235000000	rs7197779	85	84	ENST00000618327.4	Benign		rs7197779
CNTRL	chr9	121144897	121144897	C	T	c.3106C>T	Ctc/Ttc	p.L1036F	0.535	10	1	Missense Variant	Missense Variant	MODERATE	ENST00000373855.5					10	1	ENST00000373855.5
CPEB3	chr10	92239635	92239635	G	A	c.716C>T	tCg/tTg	p.S239L	0.533	3	1	Missense Variant	Missense Variant	MODERATE	ENST00000265997.5				rs772631202	3	1	ENST00000265997.5			rs772631202
CREB3L2	chr7	137928167	137928170	CTGG	C	c.299_301del	aCCAgt/agt	p.T100del	0.961	49	49	In-frame Deletion	In-frame Deletion	MODERATE	ENST00000330387.11		COSV57791862		rs3217268	49	49	ENST00000330387.11		COSV57791862	rs3217268
CUX1	chr7	102111730	102111730	C	G	c.563C>G	tCa/tGa	p.S188*	0.436	9	1	Nonsense Mutation	Nonsense Mutation	HIGH	ENST00000292535.12		COSV105874205			9	1	ENST00000292535.12		COSV105874205
DNM2	chr19	10829156	10829156	C	T	c.2179C>T	Cat/Tat	p.H727Y	0.472	6	2	Missense Variant	Missense Variant	MODERATE	ENST00000389253.9	Conflicting_interpretations_of_pathogenicity		0.000274438000	rs142963320	6	2	ENST00000389253.9	Conflicting_interpretations_of_pathogenicity		rs142963320
EP300	chr22	41178379	41178379	A	C	c.6668A>C	cAg/cCg	p.Q2223P	0.463	22	4	Missense Variant	Missense Variant	MODERATE	ENST00000263253.9	Benign	COSV54331579	0.023220900000	rs1046088	22	4	ENST00000263253.9	Benign	COSV54331579	rs1046088
FAM135B	chr8	138153029	138153030	TG	CA	c.1445_1446inv	cCA/cTG	p.P482L	0.975	35	29	Missense Variant	Missense Variant	MODERATE	ENST00000395297.6				rs71505459	35	29	ENST00000395297.6			rs71505459

CNV

There are no omics data for this model.

Histology Information for Model: BCM-15057

Patient

PDX

H&E

HER2