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Breast
HCI-038
Model Details
Patient
PDX Model
Drug Studies
Histology
Metastasis
Patient Treatment
Patient Information for Model: HCI-038
Contact Model Developer
Model Contact
Model: HCI-038
Model Contact: Alana Welm
Institution: HCI Breast PDX Program
Email:
Alana.Welm@hci.utah.edu
Patient Information
Clinical Timeline
Color Keys:
Positive
Negative
N/A
Clinical Information at Collection
Clinical Biomarkers/Mutations at Collection
Pathology Information at Collection
Model Information for Model: HCI-038
Model Details - Initial Implantation of Patient Tissue
Biomarkers & Mutations
Model Details - Acceptable Conditions for Passaging
Mutations (Cancer Gene Census List)
Mutation data is currently not available.
CNV
There are no omics data for this model.
Drug Studies for Model: HCI-038
Treatment Response Across All Studies
CR <=-95% to -100%
PR <-30% to >-95%
SD >=-30% to +20%
PD >=+20%
NA
Drug Study: PPRstudy
Study Metadata
Study ID:
PPRstudy
Study Type:
Efficacy
Study Description:
Dosing Initiation Timepoint:
Number of Arms:
3
Mouse Strain:
PI:
Alana Welm
Study Title:
PPR Study
Treatments:
Birinapant, Tolinapant
Study Duration:
Transplant Site
Transplant Material:
Study Design
Total arms showing: 3
F
P
1
N
E
Rows Per Page
10
15
25
50
Download
Study Description
Arm Type
Treatment Arms
Number of Mice
Dose (mg/kg)
Concentration (mg/ml)
Vehicle
Route
Dosing Schedule
Treatment
Birinapant
10
Treatment
Tolinapant
20
Control
Vehicle
Total arms showing: 3
F
P
1
N
E
Rows Per Page
10
15
25
50
Download
Treatment Results
Total treatment results showing: 3
F
P
1
N
E
Rows Per Page
10
15
25
50
Download
Treatment Arm
Treatment Duration
Monitoring Method
Monitor Duration
Tumor volume over time (%)
Response Category
Birinapant
21
1571
PD
Tolinapant
21
2013
PD
Vehicle
21
1484
PD
Total treatment results showing: 3
F
P
1
N
E
Rows Per Page
10
15
25
50
Download
Histology Information for Model: HCI-038
There are no histology images for this model.
Metastasis Information for Model: HCI-038
Patient
PDX
Abdomen
Adrenal gland
Bone
Bone (de novo)
Bones
Brain
CTC
Chest
Chest wall
Contralateral Breast
Dura
Fallopian Tubes
Head
Kidney
LMD
Liver
Lung
Lymph node
Lymph nodes
Neck
None
Ovary
Pancreas
Pericardium
Peritoneal cavity
Peritoneum
Pleura
Pleural effusion
Shoulder
Skin
Spine
Spleen
Thoracic Spine
Thymus
medistinal and right hilar
Patient Treatment Information for Model: HCI-038
Event Id
Treatment
Treatment Setting
Age at Start
Age at End
Duration
11
Lumpectomy
Neoadjuvant
49.08
49.16
29 days
12
Radiation with boost
Neoadjuvant
49.25
49.5
91 days
15
Tamoxifen
Neoadjuvant
53.5
55.6
767 days
18
Taxol/carboplatin
Neoadjuvant
60.5
60.75
91 days
21
Xeloda
Neoadjuvant
61.5
61.59
33 days
22
Genetic testing CHEK2 VUS: p.G342S
Neoadjuvant
61.6
61.68
29 days
23
Gabapentin
Neoadjuvant
61.7
61.75
18 days
31
Radiation Therapy
Adjuvant
62.08
62.16
29 days
Please wait...
