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Breast
HCI-010
Model Details
Patient
PDX Model
Drug Studies
Histology
Metastasis
Patient Treatment
Patient Information for Model: HCI-010
Contact Model Developer
Model Contact
Model: HCI-010
Model Contact: Alana Welm
Institution: HCI Breast PDX Program
Email:
Alana.Welm@hci.utah.edu
Patient Information
Clinical Timeline
Color Keys:
Positive
Negative
N/A
Clinical Information at Collection
Clinical Biomarkers/Mutations at Collection
Pathology Information at Collection
Model Information for Model: HCI-010
Model Details - Initial Implantation of Patient Tissue
Biomarkers & Mutations
Model Details - Acceptable Conditions for Passaging
Mutations (Cancer Gene Census List)
Mutation data is currently not available.
CNV
There are no omics data for this model.
Drug Studies for Model: HCI-010
Treatment Response Across All Studies
CR <=-95% to -100%
PR <-30% to >-95%
SD >=-30% to +20%
PD >=+20%
NA
Drug Study: Legacy2017
Study Metadata
Study ID:
Legacy2017
Study Type:
Efficacy
Study Description:
Dosing Initiation Timepoint:
Number of Arms:
16
Mouse Strain:
PI:
Alana Welm
Study Title:
Legacy 2017 - PDX Efficacy Study
Treatments:
5-Fluorouracil, MK-1775, Olaparib, Ponatinib, Doxorubicin, AZD8186, Palbociclib, TAK228, Palbociclib+AZD8186, Palbociclib+TAK228, Apitilosib, Everolimus, Gemcitabine, Paclitaxel, Lapatinib
Study Duration:
Transplant Site
Transplant Material:
Study Design
Total arms showing: 6
F
P
1
N
E
Rows Per Page
10
15
25
50
Download
Study Description
Arm Type
Treatment Arms
Number of Mice
Dose (mg/kg)
Concentration (mg/ml)
Vehicle
Route
Dosing Schedule
Treatment
TAK228
4
Control
Vehicle
4
Treatment
Palbociclib
6
Treatment
AZD8186
5
Treatment
Palbociclib+TAK228
5
Treatment
Palbociclib+AZD8186
7
Total arms showing: 6
F
P
1
N
E
Rows Per Page
10
15
25
50
Download
Treatment Results
Total treatment results showing: 6
F
P
1
N
E
Rows Per Page
10
15
25
50
Download
Treatment Arm
Treatment Duration
Monitoring Method
Monitor Duration
Tumor volume over time (%)
Response Category
TAK228
22
104
PD
Vehicle
22
237
PD
Palbociclib
22
104
PD
AZD8186
22
116
PD
Palbociclib+TAK228
22
50
PD
Palbociclib+AZD8186
22
48
PD
Total treatment results showing: 6
F
P
1
N
E
Rows Per Page
10
15
25
50
Download
Histology Information for Model: HCI-010
There are no histology images for this model.
Metastasis Information for Model: HCI-010
Patient
PDX
Abdomen
Adrenal gland
Bone
Bone (de novo)
Bones
Brain
CTC
Chest
Chest wall
Contralateral Breast
Dura
Fallopian Tubes
Head
Kidney
LMD
Liver
Lung
Lymph node
Lymph nodes
Neck
None
Ovary
Pancreas
Pericardium
Peritoneal cavity
Peritoneum
Pleura
Pleural effusion
Shoulder
Skin
Spine
Spleen
Thoracic Spine
Thymus
medistinal and right hilar
Patient Treatment Information for Model: HCI-010
Event Id
Treatment
Treatment Setting
Age at Start
Age at End
Duration
Clinical Response
Reason Stopped
10
Radiation to the chest wall, supraclavicular nodes and axilla
Neoadjuvant
47.08
47.16
29 days
15
Cyclophosphamide , Doxorubicin , Paclitaxel
Neoadjuvant
47.25
47.33
29 days
Progressive disease
20
Liposomal Doxorubicin
Neoadjuvant
48.41
48.5
33 days
Progressive disease
25
Zolendronic Acid
Neoadjuvant
48.61
48.71
37 days
Progressive disease
30
Capcitabine
Neoadjuvant
48.75
48.91
58 days
Progressive disease
35
Doxetaxel
Neoadjuvant
48.83
48.91
29 days
Progressive disease
Patient Died
Please wait...
