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Model Details

Patient Information for Model: BL8106

Model Contact

Model: BL8106
Model Contact: Seth Lerner
Institution: BCM Bladder PDX Program
Email: bladdercan@bcm.edu

Patient Information

Clinical Timeline

Clinical Information at Collection

Pathology Information at Collection

Model Information for Model: BL8106

Model Details - Initial Implantation of Patient Tissue

Mutations (Cancer Gene Census List)

GeneFilter by Gene	ChrFilter by Chr	Start	End	Ref	Alt	cDNA Change	Codon Change	Protein Change	TVAF	Gene Mutation Freq.	Site Mutation Freq.	Most Severe Effect	All Effects	Mutation Impact	Transcript ID	ClinVar Clinical Significance	COSMIC ID	gnomAD Non-Cancer AF	dbSNP ID	Gene Mutation Freq.	Site Mutation Freq.	Transcript ID	ClinVar Clinical Significance	COSMIC ID	dbSNP ID
A1CF	chr10	50809906	50809909	TAGC	T	c.1594_1596del	GCT/-	p.A532del	0.062	2	2	In-frame Deletion	In-frame Deletion	MODERATE	ENST00000373997.8		COSV50964203		rs747104061	2	2	ENST00000373997.8		COSV50964203	rs747104061
ABL1	chr9	130884102	130884105	CAAG	C	c.1826_1828del	AAG/-	p.K609del	0.028	6	6	In-frame Deletion	In-frame Deletion	MODERATE	ENST00000318560.6		COSV59324524		rs201725154	6	6	ENST00000318560.6		COSV59324524	rs201725154
ABL2	chr1	179108917	179108917	T	A	c.2350A>T	Aca/Tca	p.T784S	0.525	1	1	Missense Variant	Missense Variant	MODERATE	ENST00000502732.6	Likely_benign	COSV105243257	0.003241380000	rs55892721	1	1	ENST00000502732.6	Likely_benign	COSV105243257	rs55892721
ACSL6	chr5	131966526	131966526	C	T	c.1603G>A	Gtg/Atg	p.V535M	0.059	1	1	Missense Variant	Missense Variant	MODERATE	ENST00000651883.2				.	1	1	ENST00000651883.2			.
AFDN	chr6	167952115	167952118	CGAG	C	c.4629_4631del	GAG/-	p.E1543del	0.04	7	1	In-frame Deletion	In-frame Deletion	MODERATE	ENST00000366806.6				rs540265332	7	1	ENST00000366806.6			rs540265332
AFDN	chr6	167966011	167966014	TGAG	T	c.5091_5093del	GAG/-	p.E1697del	0.038	7	7	In-frame Deletion	In-frame Deletion	MODERATE	ENST00000366806.6		COSV60040388		.	7	7	ENST00000366806.6		COSV60040388	.
AKAP9	chr7	92085597	92085597	C	T	c.8935C>T	Cct/Tct	p.P2979S	0.968	7	7	Missense Variant	Missense Variant	MODERATE	ENST00000356239.8	Benign/Likely_benign	COSV104663065	0.996325000000	rs1063242	7	7	ENST00000356239.8	Benign/Likely_benign	COSV104663065	rs1063242
ALK	chr2	29193706	29193706	T	C	c.4381A>G	Atc/Gtc	p.I1461V	0.992	8	8	Missense Variant	Missense Variant	MODERATE	ENST00000389048.8	Benign	COSV101201052	0.997594000000	rs1670283	8	8	ENST00000389048.8	Benign	COSV101201052	rs1670283
ANK1	chr8	41661926	41661926	C	T	c.5494G>A	Gtt/Att	p.V1832I	0.025	4	1	Missense Variant	Missense Variant	MODERATE	ENST00000289734.13				.	4	1	ENST00000289734.13			.
ANK1	chr8	41688189	41688189	C	T	c.4225G>A	Gtt/Att	p.V1409I	0.515	4	1	Missense Variant	Missense Variant	MODERATE	ENST00000289734.13			0.000227892000	rs199760447	4	1	ENST00000289734.13			rs199760447
APC	chr5	112841059	112841059	T	A	c.5465T>A	gTc/gAc	p.V1822D	0.983	7	7	Missense Variant	Missense Variant	MODERATE	ENST00000257430.9	Benign	COSV57321643	0.794920000000	rs459552	7	7	ENST00000257430.9	Benign	COSV57321643	rs459552
APOBEC3B	chr22	38984190	38984190	C	T	c.133C>T	Cgc/Tgc	p.R45C	0.514	1	1	Missense Variant	Missense Variant	MODERATE	ENST00000333467.4	Likely_benign		0.001767490000	rs143126732	1	1	ENST00000333467.4	Likely_benign		rs143126732
AR	chrX	67545316	67545319	TGCA	T	c.237_239del	ctGCAg/ctg	p.Q80del	0.859	7	3	In-frame Deletion	In-frame Deletion	MODERATE	ENST00000374690.9		COSV65954886		.	7	3	ENST00000374690.9		COSV65954886	.
AR	chrX	67545400	67545403	GGCA	G	c.271_273del	agGCAg/agg	p.Q91del	0.042	7	6	In-frame Deletion	In-frame Deletion	MODERATE	ENST00000374690.9		COSV65954891		rs753526329	7	6	ENST00000374690.9		COSV65954891	rs753526329
AR	chrX	67545316	67545322	TGCAGCA	T	c.234_239del	ctGCAGCAg/ctg	p.Q79_Q80del	0.132	7	3	In-frame Deletion	In-frame Deletion	MODERATE	ENST00000374690.9		COSV65952724		.	7	3	ENST00000374690.9		COSV65952724	.

CNV

There are no omics data for this model.

Histology Information for Model: BL8106

There are no histology images for this model.

Metastasis Information for Model: BL8106

Patient

PDX

Abdomen

Adrenal

Colon

Kidney

Liver

Lung

Lymph Node

Pelvis

Peritoneum

Small Bowel

Patient Treatment Information for Model: BL8106

Event Id	Treatment	Treatment Setting	Age at Start	Age at End	Duration	Clinical Response	Pathologic Response
10	BCG	BCG +-IFN	38.53	38.64	40 days	Unknown	Unknown
15	BCG	BCG +-IFN	39.02	39.12	36 days	Progressive Disease	No response
20	BCG	BCG +-IFN	39.31	39.35	15 days	Unknown	Unknown
25	BCG	BCG +-IFN	40.25	40.29	15 days	Stable Disease	No response
40	Gemcitabine	Systemic Chemotherapy	46.62	46.62	1 day	Complete Response	Complete response
50	BCG	BCG +-IFN	48.45	48.49	15 days	Unknown	Unknown