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Model Details

Patient Information for Model: BL8090

Model Contact

Model: BL8090
Model Contact: Seth Lerner
Institution: BCM Bladder PDX Program
Email: bladdercan@bcm.edu

Patient Information

Clinical Timeline

Clinical Information at Collection

Pathology Information at Collection

Model Information for Model: BL8090

Model Details - Initial Implantation of Patient Tissue

Mutations (Cancer Gene Census List)

GeneFilter by Gene	ChrFilter by Chr	Start	End	Ref	Alt	cDNA Change	Codon Change	Protein Change	TVAF	Gene Mutation Freq.	Site Mutation Freq.	Most Severe Effect	All Effects	Mutation Impact	Transcript ID	ClinVar Clinical Significance	COSMIC ID	gnomAD Non-Cancer AF	dbSNP ID	Gene Mutation Freq.	Site Mutation Freq.	Transcript ID	ClinVar Clinical Significance	COSMIC ID	dbSNP ID
A1CF	chr10	50809906	50809909	TAGC	T	c.1594_1596del	GCT/-	p.A532del	0.035	2	2	In-frame Deletion	In-frame Deletion	MODERATE	ENST00000373997.8		COSV50964203		rs747104061	2	2	ENST00000373997.8		COSV50964203	rs747104061
ABL1	chr9	130884102	130884105	CAAG	C	c.1826_1828del	AAG/-	p.K609del	0.066	6	6	In-frame Deletion	In-frame Deletion	MODERATE	ENST00000318560.6		COSV59324524		rs201725154	6	6	ENST00000318560.6		COSV59324524	rs201725154
ACVR1	chr2	157770481	157770481	C	T	c.677G>A	aGc/aAc	p.S226N	0.05	2	1	Missense Variant	Missense Variant	MODERATE	ENST00000434821.7		COSV55117056	0.000004228080	rs1401182199	2	1	ENST00000434821.7		COSV55117056	rs1401182199
AFDN	chr6	167944041	167944041	T	C	c.3196T>C	Tcc/Ccc	p.S1066P	0.058	7	1	Missense Variant	Missense Variant	MODERATE	ENST00000366806.6				.	7	1	ENST00000366806.6			.
AFDN	chr6	167966011	167966014	TGAG	T	c.5091_5093del	GAG/-	p.E1697del	0.046	7	7	In-frame Deletion	In-frame Deletion	MODERATE	ENST00000366806.6		COSV60040388		.	7	7	ENST00000366806.6		COSV60040388	.
AFF3	chr2	99593872	99593873	CG	C	c.1863del	gcC/gc	p.D623Tfs*48	0.417	6	1	Frameshift Mutation	Frameshift Mutation	HIGH	ENST00000409579.5		COSV57841232		rs201754690	6	1	ENST00000409579.5		COSV57841232	rs201754690
AFF3	chr2	99601548	99601551	CGCT	C	c.1330_1332del	AGC/-	p.S444del	0.052	6	6	In-frame Deletion	In-frame Deletion	MODERATE	ENST00000409579.5		COSV57843239		.	6	6	ENST00000409579.5		COSV57843239	.
AFF3	chr2	99593875	99593880	CTGAGG	C	c.1856_1860del	aCCTCA/a	p.T619Sfs*72	0.417	6	1	Frameshift Mutation	Frameshift Mutation	HIGH	ENST00000409579.5		COSV57864141		rs199557232	6	1	ENST00000409579.5		COSV57864141	rs199557232
AKAP9	chr7	92001306	92001306	G	T	c.1389G>T	atG/atT	p.M463I	0.396	7	5	Missense Variant	Missense Variant	MODERATE	ENST00000356239.8	Benign	COSV62345589	0.376835000000	rs6964587	7	5	ENST00000356239.8	Benign	COSV62345589	rs6964587
AKAP9	chr7	92085597	92085597	C	T	c.8935C>T	Cct/Tct	p.P2979S	0.982	7	7	Missense Variant	Missense Variant	MODERATE	ENST00000356239.8	Benign/Likely_benign	COSV104663065	0.996325000000	rs1063242	7	7	ENST00000356239.8	Benign/Likely_benign	COSV104663065	rs1063242
AKAP9	chr7	92083384	92083384	A	G	c.8375A>G	aAt/aGt	p.N2792S	0.382	7	5	Missense Variant	Missense Variant	MODERATE	ENST00000356239.8	Benign/Likely_benign	COSV62339152	0.357813000000	rs6960867	7	5	ENST00000356239.8	Benign/Likely_benign	COSV62339152	rs6960867
AKAP9	chr7	92022864	92022864	A	AAAC	c.4004_4006dup	aaa/aAACaa	p.K1335_L1336insQ	0.403	7	5	In-frame Insertion	In-frame Insertion	MODERATE	ENST00000356239.8		COSV62337888		rs10644111	7	5	ENST00000356239.8		COSV62337888	rs10644111
ALDH2	chr12	111783222	111783222	G	A	c.284G>A	cGc/cAc	p.R95H	0.023	1	1	Missense Variant	Missense Variant	MODERATE	ENST00000261733.7		COSV55665025	0.000016978600	rs940553638	1	1	ENST00000261733.7		COSV55665025	rs940553638
ALK	chr2	29193706	29193706	T	C	c.4381A>G	Atc/Gtc	p.I1461V	0.994	8	8	Missense Variant	Missense Variant	MODERATE	ENST00000389048.8	Benign	COSV101201052	0.997594000000	rs1670283	8	8	ENST00000389048.8	Benign	COSV101201052	rs1670283
ALK	chr2	29232411	29232411	G	A	c.2525C>T	gCc/gTc	p.A842V	0.02	8	1	Missense Variant	Missense Variant	MODERATE	ENST00000389048.8				.	8	1	ENST00000389048.8			.

CNV

There are no omics data for this model.

Histology Information for Model: BL8090

There are no histology images for this model.

Metastasis Information for Model: BL8090

Patient

PDX

Abdomen

Adrenal

Colon

Kidney

Liver

Lung

Lymph Node

Pelvis

Peritoneum

Small Bowel

Patient Treatment Information for Model: BL8090

There are no treatments for this model.