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Model Details

Patient Information for Model: BL8089

Model Contact

Model: BL8089
Model Contact: Seth Lerner
Institution: BCM Bladder PDX Program
Email: bladdercan@bcm.edu

Patient Information

Clinical Timeline

Clinical Information at Collection

Pathology Information at Collection

Model Information for Model: BL8089

Model Details - Initial Implantation of Patient Tissue

Mutations (Cancer Gene Census List)

GeneFilter by Gene	ChrFilter by Chr	Start	End	Ref	Alt	cDNA Change	Codon Change	Protein Change	TVAF	Gene Mutation Freq.	Site Mutation Freq.	Most Severe Effect	All Effects	Mutation Impact	Transcript ID	ClinVar Clinical Significance	COSMIC ID	gnomAD Non-Cancer AF	dbSNP ID	Gene Mutation Freq.	Site Mutation Freq.	Transcript ID	ClinVar Clinical Significance	COSMIC ID	dbSNP ID
ALK	chr2	29193706	29193706	T	C	c.4381A>G	Atc/Gtc	p.I1461V	0.75	8	8	Missense Variant	Missense Variant	MODERATE	ENST00000389048.8	Benign	COSV101201052	0.997594000000	rs1670283	8	8	ENST00000389048.8	Benign	COSV101201052	rs1670283
ARID1A	chr1	26696959	26696962	AGCG	A	c.567_569del	aGCGgc/agc	p.G191del	0.5	8	4	In-frame Deletion	In-frame Deletion	MODERATE	ENST00000324856.13				.	8	4	ENST00000324856.13			.
AXIN2	chr17	65534045	65534045	C	T	c.2272G>A	Gcg/Acg	p.A758T	0.5	8	1	Missense Variant	Missense Variant	MODERATE	ENST00000307078.10	Conflicting_interpretations_of_pathogenicity	COSV61057162	0.001886490000	rs145007501	8	1	ENST00000307078.10	Conflicting_interpretations_of_pathogenicity	COSV61057162	rs145007501
AXIN2	chr17	65558473	65558473	G	A	c.148C>T	Cct/Tct	p.P50S	0.811	8	7	Missense Variant	Missense Variant	MODERATE	ENST00000307078.10	Benign	COSV61057354	0.474888000000	rs2240308	8	7	ENST00000307078.10	Benign	COSV61057354	rs2240308
BCR	chr22	23285182	23285182	A	G	c.2387A>G	aAt/aGt	p.N796S	0.667	8	8	Missense Variant	Missense Variant	MODERATE	ENST00000305877.13	Benign	COSV59932309	0.812555000000	rs140504	8	8	ENST00000305877.13	Benign	COSV59932309	rs140504
BIRC6	chr2	32488639	32488639	A	T	c.8020A>T	Act/Tct	p.T2674S	0.667	7	7	Missense Variant	Missense Variant	MODERATE	ENST00000421745.6	Benign	COSV70195673	0.588029000000	rs2366894	7	7	ENST00000421745.6	Benign	COSV70195673	rs2366894
CDKN1B	chr12	12718165	12718165	T	G	c.326T>G	gTc/gGc	p.V109G	0.667	6	6	Missense Variant	Missense Variant	MODERATE	ENST00000228872.9	Benign	COSV57429460	0.257887000000	rs2066827	6	6	ENST00000228872.9	Benign	COSV57429460	rs2066827
CEBPA	chr19	33302101	33302104	TCGC	T	c.311_313del	gGCGac/gac	p.G104del	0.342	8	7	In-frame Deletion	In-frame Deletion	MODERATE	ENST00000498907.3		COSV57197415		.	8	7	ENST00000498907.3		COSV57197415	.
CHD4	chr12	6577877	6577877	G	A	c.5269C>T	Cgc/Tgc	p.R1757C	0.667	7	1	Missense Variant	Missense Variant	MODERATE	ENST00000544040.7			0.000008442100	rs750402336	7	1	ENST00000544040.7			rs750402336
CIITA	chr16	10909070	10909070	A	G	c.2702A>G	cAg/cGg	p.Q901R	0.8	8	8	Missense Variant	Missense Variant	MODERATE	ENST00000618327.4	Benign		0.983235000000	rs7197779	8	8	ENST00000618327.4	Benign		rs7197779
CREB3L2	chr7	137928167	137928170	CTGG	C	c.299_301del	aCCAgt/agt	p.T100del	0.667	4	4	In-frame Deletion	In-frame Deletion	MODERATE	ENST00000330387.11		COSV57791862		rs3217268	4	4	ENST00000330387.11		COSV57791862	rs3217268
ELN	chr7	74056384	74056384	G	A	c.1264G>A	Ggt/Agt	p.G422S	0.75	7	4	Missense Variant	Missense Variant	MODERATE	ENST00000252034.12	Benign	COSV52708305	0.318730000000	rs2071307	7	4	ENST00000252034.12	Benign	COSV52708305	rs2071307
EP300	chr22	41127648	41127648	G	T	c.1068G>T	caG/caT	p.Q356H	0.667	6	1	Missense Variant	Missense Variant	MODERATE	ENST00000263253.9				.	6	1	ENST00000263253.9			.
ERCC5	chr13	102875499	102875499	G	C	c.3157G>C	Gga/Cga	p.G1053R	0.667	8	8	Missense Variant	Missense Variant	MODERATE	ENST00000652225.2	Benign	COSV100863566	0.999497000000	rs9514066	8	8	ENST00000652225.2	Benign	COSV100863566	rs9514066
ERCC5	chr13	102875896	102875896	A	C	c.3554A>C	aAa/aCa	p.K1185T	0.667	8	1	Missense Variant	Missense Variant	MODERATE	ENST00000652225.2	Uncertain_significance		0.000185603000	rs201911663	8	1	ENST00000652225.2	Uncertain_significance		rs201911663

CNV

There are no omics data for this model.

Histology Information for Model: BL8089

There are no histology images for this model.

Metastasis Information for Model: BL8089

Patient

PDX

Abdomen

Adrenal

Colon

Kidney

Liver

Lung

Lymph Node

Pelvis

Peritoneum

Small Bowel

Patient Treatment Information for Model: BL8089

There are no treatments for this model.