PDX Portal

Model Details

Patient Information for Model: BCM-PDAC-3

Model Contact

Model: BCM-PDAC-3
Model Contact: Qizhi Cathy Yao
Institution: BCM Pancreas PDX Program
Email: qizhiyao@bcm.edu

Patient Information

Clinical Timeline

Clinical Information at Collection

Clinical Biomarkers/Mutations at Collection

Pathology Information at Collection

Model Information for Model: BCM-PDAC-3

Model Details - Initial Implantation of Patient Tissue

Mutations (Cancer Gene Census List)

GeneFilter by Gene	ChrFilter by Chr	Start	End	Ref	Alt	cDNA Change	Codon Change	Protein Change	TVAF	Gene Mutation Freq.	Site Mutation Freq.	Most Severe Effect	All Effects	Mutation Impact	Transcript ID	ClinVar Clinical Significance	COSMIC ID	gnomAD Non-Cancer AF	dbSNP ID	Gene Mutation Freq.	Site Mutation Freq.	Transcript ID	ClinVar Clinical Significance	COSMIC ID	dbSNP ID
A1CF	chr10	50809906	50809909	TAGC	T	c.1594_1596del	GCT/-	p.A532del	0.03	5	4	In-frame Deletion	In-frame Deletion	MODERATE	ENST00000373997.8		COSV50964203		rs747104061	5	4	ENST00000373997.8		COSV50964203	rs747104061
ABL1	chr9	130884102	130884105	CAAG	C	c.1826_1828del	AAG/-	p.K609del	0.046	5	4	In-frame Deletion	In-frame Deletion	MODERATE	ENST00000318560.6		COSV59324524		rs201725154	5	4	ENST00000318560.6		COSV59324524	rs201725154
AFDN	chr6	167966011	167966014	TGAG	T	c.5091_5093del	GAG/-	p.E1697del	0.034	5	4	In-frame Deletion	In-frame Deletion	MODERATE	ENST00000366806.6		COSV60040388		.	5	4	ENST00000366806.6		COSV60040388	.
AFF3	chr2	99601548	99601551	CGCT	C	c.1330_1332del	AGC/-	p.S444del	0.036	5	5	In-frame Deletion	In-frame Deletion	MODERATE	ENST00000409579.5		COSV57843239		.	5	5	ENST00000409579.5		COSV57843239	.
AKAP9	chr7	92001306	92001306	G	T	c.1389G>T	atG/atT	p.M463I	0.586	8	4	Missense Variant	Missense Variant	MODERATE	ENST00000356239.8	Benign	COSV62345589	0.376835000000	rs6964587	8	4	ENST00000356239.8	Benign	COSV62345589	rs6964587
AKAP9	chr7	92085597	92085597	C	T	c.8935C>T	Cct/Tct	p.P2979S	0.996	8	8	Missense Variant	Missense Variant	MODERATE	ENST00000356239.8	Benign/Likely_benign	COSV104663065	0.996325000000	rs1063242	8	8	ENST00000356239.8	Benign/Likely_benign	COSV104663065	rs1063242
AKAP9	chr7	92083384	92083384	A	G	c.8375A>G	aAt/aGt	p.N2792S	0.605	8	4	Missense Variant	Missense Variant	MODERATE	ENST00000356239.8	Benign/Likely_benign	COSV62339152	0.357813000000	rs6960867	8	4	ENST00000356239.8	Benign/Likely_benign	COSV62339152	rs6960867
AKAP9	chr7	92022864	92022864	A	AAAC	c.4004_4006dup	aaa/aAACaa	p.K1335_L1336insQ	0.606	8	4	In-frame Insertion	In-frame Insertion	MODERATE	ENST00000356239.8		COSV62337888		rs10644111	8	4	ENST00000356239.8		COSV62337888	rs10644111
AKAP9	chr7	92003054	92003055	CA	C	c.3142del	tcA/tc	p.I1048*	0.014	8	1	Frameshift Mutation	Frameshift Mutation	HIGH	ENST00000356239.8				.	8	1	ENST00000356239.8			.
AKT1	chr14	104775735	104775738	TCTC	T	c.349_351del	GAG/-	p.E117del	0.018	3	2	In-frame Deletion	In-frame Deletion	MODERATE	ENST00000554581.5		COSV62573212		rs768025881	3	2	ENST00000554581.5		COSV62573212	rs768025881
ALK	chr2	29193500	29193500	G	C	c.4587C>G	gaC/gaG	p.D1529E	0.49	8	7	Missense Variant	Missense Variant	MODERATE	ENST00000389048.8	Benign	COSV66569695	0.472160000000	rs1881421	8	7	ENST00000389048.8	Benign	COSV66569695	rs1881421
ALK	chr2	29193706	29193706	T	C	c.4381A>G	Atc/Gtc	p.I1461V	0.997	8	8	Missense Variant	Missense Variant	MODERATE	ENST00000389048.8	Benign	COSV101201052	0.997594000000	rs1670283	8	8	ENST00000389048.8	Benign	COSV101201052	rs1670283
ALK	chr2	29193615	29193615	T	C	c.4472A>G	aAg/aGg	p.K1491R	0.49	8	7	Missense Variant	Missense Variant	MODERATE	ENST00000389048.8	Benign	COSV66555753	0.349007000000	rs1881420	8	7	ENST00000389048.8	Benign	COSV66555753	rs1881420
APC	chr5	112841059	112841059	T	A	c.5465T>A	gTc/gAc	p.V1822D	0.997	7	7	Missense Variant	Missense Variant	MODERATE	ENST00000257430.9	Benign	COSV57321643	0.794920000000	rs459552	7	7	ENST00000257430.9	Benign	COSV57321643	rs459552
APC	chr5	112841945	112841948	AGCT	A	c.6363_6365del	GCT/-	p.A2122del	0.014	7	2	In-frame Deletion	In-frame Deletion	MODERATE	ENST00000257430.9		COSV105081883		.	7	2	ENST00000257430.9		COSV105081883	.