PDX Portal

Model Details

Patient Information for Model: BCM-PDAC-26

Model Contact

Model: BCM-PDAC-26
Model Contact: Qizhi Cathy Yao
Institution: BCM Pancreas PDX Program
Email: qizhiyao@bcm.edu

Patient Information

Clinical Timeline

Clinical Information at Collection

Clinical Biomarkers/Mutations at Collection

Pathology Information at Collection

Model Information for Model: BCM-PDAC-26

Model Details - Initial Implantation of Patient Tissue

Mutations (Cancer Gene Census List)

GeneFilter by Gene	ChrFilter by Chr	Start	End	Ref	Alt	cDNA Change	Codon Change	Protein Change	TVAF	Gene Mutation Freq.	Site Mutation Freq.	Most Severe Effect	All Effects	Mutation Impact	Transcript ID	ClinVar Clinical Significance	COSMIC ID	gnomAD Non-Cancer AF	dbSNP ID	Gene Mutation Freq.	Site Mutation Freq.	Transcript ID	ClinVar Clinical Significance	COSMIC ID	dbSNP ID
GLI1	chr12	57471353	57471353	T	A	c.2613T>A	gaT/gaA	p.D871E	0.667	9	1	Missense Variant	Missense Variant	MODERATE	ENST00000228682.7				.	9	1	ENST00000228682.7			.
GLI1	chr12	57471404	57471404	T	A	c.2664T>A	caT/caA	p.H888Q	0.667	9	1	Missense Variant	Missense Variant	MODERATE	ENST00000228682.7				.	9	1	ENST00000228682.7			.
GLI1	chr12	57471394	57471394	C	A	c.2654C>A	tCc/tAc	p.S885Y	0.667	9	1	Missense Variant	Missense Variant	MODERATE	ENST00000228682.7				.	9	1	ENST00000228682.7			.
GLI1	chr12	57471392	57471392	T	A	c.2652T>A	gaT/gaA	p.D884E	0.667	9	1	Missense Variant	Missense Variant	MODERATE	ENST00000228682.7				.	9	1	ENST00000228682.7			.
GLI1	chr12	57471386	57471386	C	A	c.2646C>A	gaC/gaA	p.D882E	0.667	9	1	Missense Variant	Missense Variant	MODERATE	ENST00000228682.7				.	9	1	ENST00000228682.7			.
GLI1	chr12	57471366	57471366	G	C	c.2626G>C	Gaa/Caa	p.E876Q	0.667	9	1	Missense Variant	Missense Variant	MODERATE	ENST00000228682.7				.	9	1	ENST00000228682.7			.
KIAA1549	chr7	138916960	138916960	C	A	c.2666G>T	gGt/gTt	p.G889V	0.667	7	2	Missense Variant	Missense Variant	MODERATE	ENST00000422774.2	Benign	COSV54314278	0.061678000000	rs2354336	7	2	ENST00000422774.2	Benign	COSV54314278	rs2354336
PRKCB	chr16	24035419	24035419	C	T	c.401C>T	aCc/aTc	p.T134I	0.667	1	1	Missense Variant	Missense Variant; Splice Region Variant	MODERATE	ENST00000643927.1				.	1	1	ENST00000643927.1			.
PTPN6	chr12	6954954	6954954	G	T	c.476G>T	gGc/gTc	p.G159V	0.5	1	1	Missense Variant	Missense Variant	MODERATE	ENST00000318974.14				rs1945999159	1	1	ENST00000318974.14			rs1945999159
ROBO2	chr3	77098067	77098067	G	T	c.163G>T	Gat/Tat	p.D55Y	0.667	3	1	Missense Variant	Missense Variant	MODERATE	ENST00000487694.7				rs760073973	3	1	ENST00000487694.7			rs760073973
ROBO2	chr3	77098070	77098070	G	T	c.166G>T	Gtc/Ttc	p.V56F	0.667	3	1	Missense Variant	Missense Variant	MODERATE	ENST00000487694.7				.	3	1	ENST00000487694.7			.
ROBO2	chr3	77098074	77098074	T	C	c.170T>C	aTc/aCc	p.I57T	0.667	3	1	Missense Variant	Missense Variant	MODERATE	ENST00000487694.7				.	3	1	ENST00000487694.7			.
ROBO2	chr3	77098079	77098079	T	C	c.175T>C	Tct/Cct	p.S59P	0.667	3	1	Missense Variant	Missense Variant	MODERATE	ENST00000487694.7				.	3	1	ENST00000487694.7			.
SH2B3	chr12	111446804	111446804	T	C	c.784T>C	Tgg/Cgg	p.W262R	0.75	8	8	Missense Variant	Missense Variant	MODERATE	ENST00000341259.7	Benign	COSV57981059	0.673459000000	rs3184504	8	8	ENST00000341259.7	Benign	COSV57981059	rs3184504
THRAP3	chr1	36286684	36286684	G	T	c.454G>T	Gac/Tac	p.D152Y	0.667	1	1	Missense Variant	Missense Variant	MODERATE	ENST00000354618.10				.	1	1	ENST00000354618.10			.

CNV

There are no omics data for this model.

Histology Information for Model: BCM-PDAC-26

There are no histology images for this model.

Metastasis Information for Model: BCM-PDAC-26

Patient

PDX

Liver

Local

Local recurrence

Lung

Rectum

lymph node

Patient Treatment Information for Model: BCM-PDAC-26

Event Id	Treatment	Treatment Setting	Age at Start	Age at End	Duration	Clinical Response	Pathologic Response	Reason Stopped
15	Gemcitabine/capecitabine	Adjuvant	46.83	47.32	179 days	Stable Disease (SD)	Not Reported	Completed regimen