PDX Portal

Model Details

Patient Information for Model: BCM-PDAC-13

Model Contact

Model: BCM-PDAC-13
Model Contact: Qizhi Cathy Yao
Institution: BCM Pancreas PDX Program
Email: qizhiyao@bcm.edu

Patient Information

Clinical Timeline

Clinical Information at Collection

Clinical Biomarkers/Mutations at Collection

Pathology Information at Collection

Model Information for Model: BCM-PDAC-13

Model Details - Initial Implantation of Patient Tissue

Mutations (Cancer Gene Census List)

GeneFilter by Gene	ChrFilter by Chr	Start	End	Ref	Alt	cDNA Change	Codon Change	Protein Change	TVAF	Gene Mutation Freq.	Site Mutation Freq.	Most Severe Effect	All Effects	Mutation Impact	Transcript ID	ClinVar Clinical Significance	COSMIC ID	gnomAD Non-Cancer AF	dbSNP ID	Gene Mutation Freq.	Site Mutation Freq.	Transcript ID	ClinVar Clinical Significance	COSMIC ID	dbSNP ID
A1CF	chr10	50809906	50809909	TAGC	T	c.1594_1596del	GCT/-	p.A532del	0.024	5	4	In-frame Deletion	In-frame Deletion	MODERATE	ENST00000373997.8		COSV50964203		rs747104061	5	4	ENST00000373997.8		COSV50964203	rs747104061
ABL1	chr9	130884102	130884105	CAAG	C	c.1826_1828del	AAG/-	p.K609del	0.047	5	4	In-frame Deletion	In-frame Deletion	MODERATE	ENST00000318560.6		COSV59324524		rs201725154	5	4	ENST00000318560.6		COSV59324524	rs201725154
AFDN	chr6	167966011	167966014	TGAG	T	c.5091_5093del	GAG/-	p.E1697del	0.029	5	4	In-frame Deletion	In-frame Deletion	MODERATE	ENST00000366806.6		COSV60040388		.	5	4	ENST00000366806.6		COSV60040388	.
AFF3	chr2	99593618	99593620	CAG	C	c.2116_2117del	CTg/g	p.L706Gfs*24	0.011	5	1	Frameshift Mutation	Frameshift Mutation	HIGH	ENST00000409579.5				.	5	1	ENST00000409579.5			.
AFF3	chr2	99601548	99601551	CGCT	C	c.1330_1332del	AGC/-	p.S444del	0.049	5	5	In-frame Deletion	In-frame Deletion	MODERATE	ENST00000409579.5		COSV57843239		.	5	5	ENST00000409579.5		COSV57843239	.
AFF3	chr2	99593652	99593652	G	C	c.2084C>G	tCg/tGg	p.S695W	0.581	5	1	Missense Variant	Missense Variant	MODERATE	ENST00000409579.5				rs1436457705	5	1	ENST00000409579.5			rs1436457705
AFF3	chr2	99593623	99593623	C	CCT	c.2112_2113insAG	-/AG	p.D705Rfs*30	0.011	5	1	Frameshift Mutation	Frameshift Mutation	HIGH	ENST00000409579.5				.	5	1	ENST00000409579.5			.
AFF3	chr2	99593622	99593622	T	A	c.2114A>T	gAc/gTc	p.D705V	0.01	5	1	Missense Variant	Missense Variant	MODERATE	ENST00000409579.5				.	5	1	ENST00000409579.5			.
AKAP9	chr7	92042077	92042079	CAG	C	c.4960_4961del	tcAGag/tcag	p.R1654Gfs*23	0.027	8	2	Frameshift Mutation	Frameshift Mutation	HIGH	ENST00000356239.8		COSV62338254		rs779447911	8	2	ENST00000356239.8		COSV62338254	rs779447911
AKAP9	chr7	92085597	92085597	C	T	c.8935C>T	Cct/Tct	p.P2979S	0.998	8	8	Missense Variant	Missense Variant	MODERATE	ENST00000356239.8	Benign/Likely_benign	COSV104663065	0.996325000000	rs1063242	8	8	ENST00000356239.8	Benign/Likely_benign	COSV104663065	rs1063242
AKAP9	chr7	92042077	92042077	C	CAG	c.4960_4961dup	tca/tcAGa	p.V1655Gfs*4	0.017	8	1	Frameshift Mutation	Frameshift Mutation	HIGH	ENST00000356239.8		COSV62350299		.	8	1	ENST00000356239.8		COSV62350299	.
ALK	chr2	29193500	29193500	G	C	c.4587C>G	gaC/gaG	p.D1529E	0.249	8	7	Missense Variant	Missense Variant	MODERATE	ENST00000389048.8	Benign	COSV66569695	0.472160000000	rs1881421	8	7	ENST00000389048.8	Benign	COSV66569695	rs1881421
ALK	chr2	29193706	29193706	T	C	c.4381A>G	Atc/Gtc	p.I1461V	0.999	8	8	Missense Variant	Missense Variant	MODERATE	ENST00000389048.8	Benign	COSV101201052	0.997594000000	rs1670283	8	8	ENST00000389048.8	Benign	COSV101201052	rs1670283
ALK	chr2	29193615	29193615	T	C	c.4472A>G	aAg/aGg	p.K1491R	0.24	8	7	Missense Variant	Missense Variant	MODERATE	ENST00000389048.8	Benign	COSV66555753	0.349007000000	rs1881420	8	7	ENST00000389048.8	Benign	COSV66555753	rs1881420
ANK1	chr8	41708920	41708920	C	T	c.1856G>A	cGt/cAt	p.R619H	0.266	5	3	Missense Variant	Missense Variant	MODERATE	ENST00000289734.13	Benign/Likely_benign	COSV55882618	0.044445800000	rs2304877	5	3	ENST00000289734.13	Benign/Likely_benign	COSV55882618	rs2304877

CNV

Histology Information for Model: BCM-PDAC-13

There are no histology images for this model.

Metastasis Information for Model: BCM-PDAC-13

Patient

PDX

Liver

Local

Local recurrence

Lung

Rectum

lymph node

Patient Treatment Information for Model: BCM-PDAC-13

Event Id	Treatment	Treatment Setting	Age at Start	Age at End	Duration	Clinical Response	Pathologic Response	Reason Stopped
5	Gemcitabine/Abraxane	Neoadjuvant	64.9	65.09	69 days	Stable Disease (SD); CA 19-9 dropped from 504-184	No Response (NR)	Treatment Completed
15	Gemcitabine/Abraxane	Adjuvant	65.46	65.48	7 days			Poor performance status