PDX Portal

Model Details

Patient Information for Model: BCM-PDAC-10

Model Contact

Model: BCM-PDAC-10
Model Contact: Qizhi Cathy Yao
Institution: BCM Pancreas PDX Program
Email: qizhiyao@bcm.edu

Patient Information

Clinical Timeline

Clinical Information at Collection

Clinical Biomarkers/Mutations at Collection

Pathology Information at Collection

Model Information for Model: BCM-PDAC-10

Model Details - Initial Implantation of Patient Tissue

Mutations (Cancer Gene Census List)

GeneFilter by Gene	ChrFilter by Chr	Start	End	Ref	Alt	cDNA Change	Codon Change	Protein Change	TVAF	Gene Mutation Freq.	Site Mutation Freq.	Most Severe Effect	All Effects	Mutation Impact	Transcript ID	ClinVar Clinical Significance	COSMIC ID	gnomAD Non-Cancer AF	dbSNP ID	Gene Mutation Freq.	Site Mutation Freq.	Transcript ID	ClinVar Clinical Significance	COSMIC ID	dbSNP ID
AKAP9	chr7	92001075	92001075	A	T	c.1158A>T	aaA/aaT	p.K386N	0.485	8	2	Missense Variant	Missense Variant	MODERATE	ENST00000356239.8	Conflicting_interpretations_of_pathogenicity		0.000153447000	rs142673316	8	2	ENST00000356239.8	Conflicting_interpretations_of_pathogenicity		rs142673316
AKAP9	chr7	92085597	92085597	C	T	c.8935C>T	Cct/Tct	p.P2979S	0.992	8	8	Missense Variant	Missense Variant	MODERATE	ENST00000356239.8	Benign/Likely_benign	COSV104663065	0.996325000000	rs1063242	8	8	ENST00000356239.8	Benign/Likely_benign	COSV104663065	rs1063242
ALK	chr2	29193500	29193500	G	C	c.4587C>G	gaC/gaG	p.D1529E	0.502	8	7	Missense Variant	Missense Variant	MODERATE	ENST00000389048.8	Benign	COSV66569695	0.472160000000	rs1881421	8	7	ENST00000389048.8	Benign	COSV66569695	rs1881421
ALK	chr2	29193706	29193706	T	C	c.4381A>G	Atc/Gtc	p.I1461V	0.995	8	8	Missense Variant	Missense Variant	MODERATE	ENST00000389048.8	Benign	COSV101201052	0.997594000000	rs1670283	8	8	ENST00000389048.8	Benign	COSV101201052	rs1670283
ALK	chr2	29193615	29193615	T	C	c.4472A>G	aAg/aGg	p.K1491R	0.497	8	7	Missense Variant	Missense Variant	MODERATE	ENST00000389048.8	Benign	COSV66555753	0.349007000000	rs1881420	8	7	ENST00000389048.8	Benign	COSV66555753	rs1881420
ANK1	chr8	41690485	41690485	T	C	c.3973A>G	Atg/Gtg	p.M1325V	0.497	5	3	Missense Variant	Missense Variant	MODERATE	ENST00000289734.13	Benign		0.013245000000	rs10093583	5	3	ENST00000289734.13	Benign		rs10093583
ANK1	chr8	41724513	41724513	G	T	c.654C>A	aaC/aaA	p.N218K	0.048	5	3	Missense Variant	Missense Variant	MODERATE	ENST00000289734.13	Benign/Likely_benign		0.011266600000	rs61735313	5	3	ENST00000289734.13	Benign/Likely_benign		rs61735313
ANK1	chr8	41708920	41708920	C	T	c.1856G>A	cGt/cAt	p.R619H	0.497	5	3	Missense Variant	Missense Variant	MODERATE	ENST00000289734.13	Benign/Likely_benign	COSV55882618	0.044445800000	rs2304877	5	3	ENST00000289734.13	Benign/Likely_benign	COSV55882618	rs2304877
APC	chr5	112841059	112841059	T	A	c.5465T>A	gTc/gAc	p.V1822D	0.954	7	7	Missense Variant	Missense Variant	MODERATE	ENST00000257430.9	Benign	COSV57321643	0.794920000000	rs459552	7	7	ENST00000257430.9	Benign	COSV57321643	rs459552
APOBEC3B	chr22	38989518	38989518	C	T	c.631C>T	Cgg/Tgg	p.R211W	0.329	3	3	Missense Variant	Missense Variant	MODERATE	ENST00000333467.4	Likely_benign	COSV59841187	0.000312383000	rs200770515	3	3	ENST00000333467.4	Likely_benign	COSV59841187	rs200770515
ARHGEF10	chr8	1909425	1909425	G	A	c.2098G>A	Gtt/Att	p.V700I	0.528	3	2	Missense Variant	Missense Variant	MODERATE	ENST00000349830.8	Benign	COSV50643436	0.031365600000	rs2294039	3	2	ENST00000349830.8	Benign	COSV50643436	rs2294039
ARID1A	chr1	26779439	26779439	T	TG	c.5548dup	-/G	p.D1850Gfs*4	0.567	6	2	Frameshift Mutation	Frameshift Mutation	HIGH	ENST00000324856.13		COSV61371153		rs758608743	6	2	ENST00000324856.13		COSV61371153	rs758608743
ARID1B	chr6	156778366	156778366	G	A	c.686G>A	gGc/gAc	p.G229D	0.222	6	1	Missense Variant	Missense Variant	MODERATE	ENST00000636930.2				rs1208360824	6	1	ENST00000636930.2			rs1208360824
ARID1B	chr6	156779262	156779262	G	GCGC	c.1597_1599dup	gcg/gCGCcg	p.P533dup	0.356	6	3	In-frame Insertion	In-frame Insertion	MODERATE	ENST00000636930.2		COSV51649563		.	6	3	ENST00000636930.2		COSV51649563	.
ATM	chr11	108254034	108254034	T	C	c.2119T>C	Tct/Cct	p.S707P	0.485	6	2	Missense Variant	Missense Variant	MODERATE	ENST00000278616.8	Benign/Likely_benign	COSV53743430	0.007819920000	rs4986761	6	2	ENST00000278616.8	Benign/Likely_benign	COSV53743430	rs4986761