Model Details

Patient Information for Model: BCM-15115

Patient Information
Clinical Timeline

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Clinical Information at Collection
Clinical Biomarkers/Mutations at Collection
Pathology Information at Collection

Model Information for Model: BCM-15115

Biomarkers & Mutations
Model Details
Mutations (Cancer Gene Census List)

The number of models in this collection with mutations in the listed gene
The number of models in this collection with mutations at the listed site
GeneChrStartEndRefAltcDNA ChangeCodon ChangeProtein ChangeTVAF Gene Mutation Freq. Site Mutation Freq.Most Severe EffectAll EffectsMutation ImpactTranscript IDClinVar Clinical SignificanceCOSMIC IDgnomAD Non-Cancer AFdbSNP IDGene Mutation Freq.Site Mutation Freq.Transcript IDClinVar Clinical SignificanceCOSMIC IDdbSNP ID
ABI1chr102674228526742285AG0.9494034Downstream Gene Variantdownstream_gene_variantMODIFIERNM_005470.3


rs10764638
4034NM_005470.3rs10764638
ACSL6chr5131945413131945413GC0.934718Downstream Gene Variantdownstream_gene_variantMODIFIERNM_001009185.2


rs652839
4718NM_001009185.2rs652839
ACSL6chr5131947848131947848GAG0.8894719Downstream Gene Variantdownstream_gene_variantMODIFIERNM_001009185.2


rs34365565
4719NM_001009185.2rs34365565
AFDNchr6167976539167976540TTGG0.429204Downstream Gene Variantdownstream_gene_variantMODIFIERNM_001291964.1



204NM_001291964.1
AFF1chr48713577387135773AG0.9680803' UTR variant3_prime_UTR_variantMODIFIERNM_001166693.2


rs342464
8080NM_001166693.2rs342464
AKAP9chr79194097691940976GC0.52868645' UTR variant5_prime_UTR_variantMODIFIERNM_005751.4


rs4727267
6864NM_005751.4rs4727267
AKT2chr194023381440233814GT0.97650473' UTR variant3_prime_UTR_variantMODIFIERNM_001626.5


rs2304186
5047NM_001626.5rs2304186
AKT2chr194023395840233958GA0.306501Splice Region Variantsplice_region_variant, intron_variantLOWNM_001626.5


0.000317314000rs191069336
501NM_001626.5rs191069336
ARchrX6754531667545322TTGCAGCAc.234_239dupGCAGCAp.Gln79_Gln80dup0.689452In-frame Insertion (Disruptive)disruptive_inframe_insertionMODERATENM_000044.3

COSM5826564
rs3032358
452NM_000044.3COSM5826564rs3032358
ARHGEF10chr819093901909390GAc.2135G>AaGc/aAcp.Ser712Asn0.40591Missense Variantmissense_variantMODERATENM_001308153.1


0.000818752000rs143290224
91NM_001308153.1rs143290224
ARHGEF10Lchr11761936417619364GCGc.862delCp.Leu288fs0.063771Frameshift Mutationframeshift_variantHIGHNM_018125.3



771NM_018125.3
ARHGEF10Lchr11769750217697503GGC0.91677773' UTR variant3_prime_UTR_variantMODIFIERNM_018125.3


rs3835471
7777NM_018125.3rs3835471
ARHGEF10Lchr11762299117622991GA0.491771Splice Region Variantsplice_region_variant, intron_variantLOWNM_018125.3


0.000012912000rs367933541
771NM_018125.3rs367933541
ASXL1chr203243461032434610AGc.1898A>GcAt/cGtp.His633Arg0.377492Missense Variantmissense_variantMODERATENM_015338.5


0.000129922000rs201280462
492NM_015338.5rs201280462
ASXL1chr203243742832437428TC0.69449433' UTR variant3_prime_UTR_variantMODIFIERNM_015338.5


rs2295763
4943NM_015338.5rs2295763
CNV


Histology Information for Model: BCM-15115
There are no histology images for this model.













Metastasis Information for Model: BCM-15115
 
Patient
PDX
Abdomen
Anterosuperior mediastinum
Bone
Brain
CTC
Chest
Chest wall
Contralateral breast
Fallopian tubes
Hip
Kidney
Leg bone
Liver
Lung
Lymph Node
Mediastinum
Neck
Other
Ovary
Pancreas
Paratracheal adenopathy
Pericardium
Peritoneal cavity
Peritoneum
Pleura
Pleural Cavitiy
Pleural effusion
Posterior cervical nodes
SVC node
Skin
Thymus

Patient Treatment Information for Model: BCM-15115

Event IdTreatmentTreatment SettingAge at StartAge at EndDurationClinical ResponsePathologic ResponseReason Stopped
7AnastrazoleNeoadjuvant63.8864.17106 daysResidual DiseaseNot ReportedTreatment Completed
12PaclitaxelAdjuvant64.4264.5547 daysNot ReportedNot ApplicableTreatment Completed
13Radiation Therapy (RT)Adjuvant64.6164.6929 daysNot ReportedNot ApplicableTreatment Completed












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