Model Details

Patient Information for Model: BCM-15100

Patient Information
Clinical Timeline

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Clinical Information at Collection
Clinical Biomarkers/Mutations at Collection
Pathology Information at Collection

Model Information for Model: BCM-15100

Biomarkers & Mutations
Model Details
Mutations (Cancer Gene Census List)

The number of models in this collection with mutations in the listed gene
The number of models in this collection with mutations at the listed site
GeneChrStartEndRefAltcDNA ChangeCodon ChangeProtein ChangeTVAF Gene Mutation Freq. Site Mutation Freq.Most Severe EffectAll EffectsMutation ImpactTranscript IDClinVar Clinical SignificanceCOSMIC IDgnomAD Non-Cancer AFdbSNP IDGene Mutation Freq.Site Mutation Freq.Transcript IDClinVar Clinical SignificanceCOSMIC IDdbSNP ID
ABI1chr102674228526742285AG0.54034Downstream Gene Variantdownstream_gene_variantMODIFIERNM_005470.3


rs10764638
4034NM_005470.3rs10764638
ACSL6chr5132011827132011827GA0.4724724Upstream Gene Variantupstream_gene_variantMODIFIERNM_001009185.2


rs4705908
4724NM_001009185.2rs4705908
ACSL6chr5132011827132011827GA0.4724724Intragenic Variantintragenic_variantMODIFIER


rs4705908
4724rs4705908
AFF1chr48713577387135773AG0.97680803' UTR variant3_prime_UTR_variantMODIFIERNM_001166693.2


rs342464
8080NM_001166693.2rs342464
APOBEC3Bchr223898211638982116TG0.6252623Upstream Gene Variantupstream_gene_variantMODIFIERNM_004900.4


rs2267401
2623NM_004900.4rs2267401
ARHGEF10Lchr11769750217697503GGC0.95377773' UTR variant3_prime_UTR_variantMODIFIERNM_018125.3


rs3835471
7777NM_018125.3rs3835471
ARHGEF12chr11120477419120477419GTTTG0.12281Splice Region Variantsplice_region_variant, intron_variantLOWNM_015313.2


rs781186647
81NM_015313.2rs781186647
ARHGEF12chr11120477419120477424GTTTGTTTTT0.16381Splice Region Variantsplice_region_variant, intron_variantLOWNM_015313.2


rs781186647
81NM_015313.2rs781186647
ARHGEF12chr11120477419120477421GTTTGTT0.23781Splice Region Variantsplice_region_variant, intron_variantLOWNM_015313.2


rs781186647
81NM_015313.2rs781186647
ATICchr2215311925215311925AG0.9727974Upstream Gene Variantupstream_gene_variantMODIFIERNM_004044.6


rs78631308
7974NM_004044.6rs78631308
ATICchr2215349769215349769TG0.5979613' UTR variant3_prime_UTR_variantMODIFIERNM_004044.6

COSN19749524
rs10498036
7961NM_004044.6COSN19749524rs10498036
ATP1A1chr1116406090116406090GA1.04948Downstream Gene Variantdownstream_gene_variantMODIFIERNM_000701.7


rs850610
4948NM_000701.7rs850610
ATRXchrX7768247177682471CGc.2785G>CGag/Cagp.Glu929Gln0.9855452Missense Variantmissense_variantMODERATENM_000489.4


rs3088074
5452NM_000489.4rs3088074
AXIN1chr16287017287017GA0.716225Downstream Gene Variantdownstream_gene_variantMODIFIERNM_003502.3

COSN6645580
rs449401
6225NM_003502.3COSN6645580rs449401
B2Mchr154471116644711166TG0.9764845Upstream Gene Variantupstream_gene_variantMODIFIERNM_004048.2

COSN15632065
rs2255235
4845NM_004048.2COSN15632065rs2255235
CNV


Histology Information for Model: BCM-15100
There are no histology images for this model.













Metastasis Information for Model: BCM-15100
 
Patient
PDX
Abdomen
Anterosuperior mediastinum
Bone
Brain
CTC
Chest
Chest wall
Contralateral Breast
Fallopian tubes
Hip
Kidney
Leg bone
Liver
Lung
Lymph Node
Mediastinum
Neck
Other
Ovary
Pancreas
Paratracheal adenopathy
Pericardium
Peritoneal cavity
Peritoneum
Pleura
Pleural Cavitiy
Pleural effusion
Posterior cervical nodes
SVC node
Skin
Thymus

Patient Treatment Information for Model: BCM-15100

Event IdTreatmentTreatment SettingAge at StartAge at EndDurationReason Stopped
15Cyclophosphamide,DocetaxelAdjuvant38.1138.3691 daysTreatment Completed
20Radiation Therapy (RT)Adjuvant38.3638.4429 daysTreatment Completed
25TamoxifenAdjuvant38.5339.67416 daysDisease Progression
35Leuprolide,OtherMetastatic39.6639.7533 days
40Letrozole,OtherMetastatic39.7542.12865 daysSide Effects
45OophorectomyMetastatic39.8139.81Unknown
55TamoxifenMetastatic42.1242.134 daysDisease Progression
60Other,PaclitaxelMetastatic42.1742.4188 days
70Fulvestrant,OtherMetastatic42.4343.29314 daysDisease Progression
85Capecitabine,OtherMetastatic43.344.04270 daysDisease Progression
100Fulvestrant,PalbociclibMetastatic44.1644.65179 daysDisease Progression
120DoxorubicinMetastatic44.7745.37219 daysDisease Progression
130EribulinMetastatic45.4845.780 daysDisease Progression
145CarboplatinMetastatic45.745.7311 daysSide Effects
150Radiation Therapy (RT)Metastatic45.820.0UnknownTreatment Completed












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