Model Details

Patient Information for Model: BCM-15057

Patient Information
Clinical Timeline

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Clinical Information at Collection
Clinical Biomarkers/Mutations at Collection
Pathology Information at Collection

Model Information for Model: BCM-15057

Biomarkers & Mutations
Model Details
Mutations (Cancer Gene Census List)

The number of models in this collection with mutations in the listed gene
The number of models in this collection with mutations at the listed site
GeneChrStartEndRefAltcDNA ChangeCodon ChangeProtein ChangeTVAF Gene Mutation Freq. Site Mutation Freq.Most Severe EffectAll EffectsMutation ImpactTranscript IDClinVar Clinical SignificanceCOSMIC IDgnomAD Non-Cancer AFdbSNP IDGene Mutation Freq.Site Mutation Freq.Transcript IDClinVar Clinical SignificanceCOSMIC IDdbSNP ID
ABI1chr102674228526742285AG0.5694034Downstream Gene Variantdownstream_gene_variantMODIFIERNM_005470.3


rs10764638
4034NM_005470.3rs10764638
ACSL3chr2222908920222908920GAc.148G>AGaa/Aaap.Glu50Lys0.45731Missense Variantmissense_variantMODERATENM_004457.3



31NM_004457.3
ACSL6chr5132011827132011827GA0.9924724Upstream Gene Variantupstream_gene_variantMODIFIERNM_001009185.2


rs4705908
4724NM_001009185.2rs4705908
ACSL6chr5132011827132011827GA0.9924724Intragenic Variantintragenic_variantMODIFIER


rs4705908
4724rs4705908
AFF1chr48713577387135773AG0.97380803' UTR variant3_prime_UTR_variantMODIFIERNM_001166693.2


rs342464
8080NM_001166693.2rs342464
AKT2chr194023381440233814GT0.43350473' UTR variant3_prime_UTR_variantMODIFIERNM_001626.5


rs2304186
5047NM_001626.5rs2304186
APOBEC3Bchr223898211638982116TG0.9512623Upstream Gene Variantupstream_gene_variantMODIFIERNM_004900.4


rs2267401
2623NM_004900.4rs2267401
ARHGEF10chr819568821956882CAc.3726C>AgaC/gaAp.Asp1242Glu0.96891Missense Variantmissense_variantMODERATENM_001308153.1


0.000877889000rs139515492
91NM_001308153.1rs139515492
ASXL1chr203243742832437428TC0.93949433' UTR variant3_prime_UTR_variantMODIFIERNM_015338.5


rs2295763
4943NM_015338.5rs2295763
ATICchr2215311925215311925AG0.9697974Upstream Gene Variantupstream_gene_variantMODIFIERNM_004044.6


rs78631308
7974NM_004044.6rs78631308
ATICchr2215349769215349769TG0.51479613' UTR variant3_prime_UTR_variantMODIFIERNM_004044.6

COSN19749524
rs10498036
7961NM_004044.6COSN19749524rs10498036
ATICchr2215312084215312084TG0.53479235' UTR variant5_prime_UTR_variantMODIFIERNM_004044.6


rs4535042
7923NM_004044.6rs4535042
AXIN1chr16282558282558CGC0.4476250Downstream Gene Variantdownstream_gene_variantMODIFIERNM_003502.3


rs61572786
6250NM_003502.3rs61572786
B2Mchr154471116644711166TG0.9744845Upstream Gene Variantupstream_gene_variantMODIFIERNM_004048.2

COSN15632065
rs2255235
4845NM_004048.2COSN15632065rs2255235
BARD1chr2214767531214767532CATGc.1518_1519delTGinsCAp.Val506Met0.5034223Missense Variantmissense_variantMODERATENM_000465.3



4223NM_000465.3
CNV


Histology Information for Model: BCM-15057

Patient

PDX

H&E

ER

PR

HER2


Metastasis Information for Model: BCM-15057
 
Patient
PDX
Abdomen
Anterosuperior mediastinum
Bone
Brain
CTC
Chest
Chest wall
Contralateral Breast
Fallopian tubes
Hip
Kidney
Leg bone
Liver
Lung
Lymph Node
Mediastinum
Neck
Other
Ovary
Pancreas
Paratracheal adenopathy
Pericardium
Peritoneal cavity
Peritoneum
Pleura
Pleural Cavitiy
Pleural effusion
Posterior cervical nodes
SVC node
Skin
Thymus

Patient Treatment Information for Model: BCM-15057

Event IdTreatmentTreatment SettingAge at StartAge at EndDurationClinical ResponsePathologic ResponseReason Stopped
8AnastrazoleNeoadjuvant80.1681.14358 daysNot ReportedNot ReportedTreatment Completed
17PaclitaxelAdjuvant81.2581.5195 daysNot ReportedNot ApplicableTreatment Completed
19Radiation Therapy (RT)Adjuvant81.5481.6747 daysNot ReportedNot ApplicableTreatment Completed
22ExemestaneAdjuvant81.782.58321 daysNo Response (NR)Not ApplicableDisease Progression












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