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Breast
BCM-15057
Model Details
Patient
PDX Model
Histology
Metastasis
Patient Treatment
Patient Information for Model: BCM-15057
Patient Information
Clinical Timeline
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N/A
Clinical Information at Collection
Clinical Biomarkers/Mutations at Collection
Pathology Information at Collection
Model Information for Model: BCM-15057
Model Details - Initial Implantation of Patient Tissue
Biomarkers & Mutations
Model Details - Acceptable Conditions for Passaging
Mutations (Cancer Gene Census List)
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The number of models in this collection with mutations in the listed gene;
may include models that are not publicly available for distribution.
The number of models in this collection with mutations at the listed site;
may include models that are not publicly available for distribution.
Total mutations showing: 74
F
P
1
2
3
4
5
N
E
Rows Per Page
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Gene
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cDNA Change
Codon Change
Protein Change
TVAF
Gene Mutation Freq.
Site Mutation Freq.
Most Severe Effect
All Effects
Mutation Impact
Transcript ID
ClinVar Clinical Significance
COSMIC ID
gnomAD Non-Cancer AF
dbSNP ID
Gene Mutation Freq.
Site Mutation Freq.
Transcript ID
ClinVar Clinical Significance
COSMIC ID
dbSNP ID
ACSL3
chr2
222908920
222908920
G
A
c.148G>A
Gaa/Aaa
p.E50K
0.457
2
1
Missense Variant
Missense Variant
MODERATE
ENST00000357430.8
2
1
ENST00000357430.8
AKAP9
chr7
92022864
92022864
A
AAAC
c.4004_4006dup
aaa/aAACaa
p.K1335_L1336insQ
0.974
50
35
In-frame Insertion
In-frame Insertion
MODERATE
ENST00000356239.8
COSV62337888
rs10644111
50
35
ENST00000356239.8
COSV62337888
rs10644111
ARHGEF10
chr8
1956882
1956882
C
A
c.3654C>A
gaC/gaA
p.D1218E
0.968
10
1
Missense Variant
Missense Variant
MODERATE
ENST00000349830.8
0.000877889000
rs139515492
10
1
ENST00000349830.8
rs139515492
BARD1
chr2
214767531
214767532
CA
TG
c.1518_1519inv
caTGtg/caCAtg
p.V507M
0.503
34
24
Missense Variant
Missense Variant
MODERATE
ENST00000260947.9
COSV105837301
rs386654966
34
24
ENST00000260947.9
COSV105837301
rs386654966
BRCA2
chr13
32394781
32394781
C
G
c.9349C>G
Cat/Gat
p.H3117D
0.04
21
1
Missense Variant
Missense Variant
MODERATE
ENST00000380152.7
21
1
ENST00000380152.7
CEBPA
chr19
33301825
33301825
G
GGCGGGT
c.584_589dup
ccg/cACCCGCcg
p.H195_P196dup
0.449
9
6
In-frame Insertion
In-frame Insertion
MODERATE
ENST00000498907.3
COSV57196906
9
6
ENST00000498907.3
COSV57196906
CIITA
chr16
10907647
10907647
G
A
c.2158G>A
Gcc/Acc
p.A720T
0.968
85
1
Missense Variant
Missense Variant
MODERATE
ENST00000618327.4
0.000008444590
rs755306140
85
1
ENST00000618327.4
rs755306140
CIITA
chr16
10909070
10909070
A
G
c.2702A>G
cAg/cGg
p.Q901R
0.984
85
84
Missense Variant
Missense Variant
MODERATE
ENST00000618327.4
Benign
0.983235000000
rs7197779
85
84
ENST00000618327.4
Benign
rs7197779
CNTRL
chr9
121144897
121144897
C
T
c.3106C>T
Ctc/Ttc
p.L1036F
0.535
10
1
Missense Variant
Missense Variant
MODERATE
ENST00000373855.5
10
1
ENST00000373855.5
CPEB3
chr10
92239635
92239635
G
A
c.716C>T
tCg/tTg
p.S239L
0.533
3
1
Missense Variant
Missense Variant
MODERATE
ENST00000265997.5
rs772631202
3
1
ENST00000265997.5
rs772631202
CREB3L2
chr7
137928167
137928170
CTGG
C
c.299_301del
aCCAgt/agt
p.T100del
0.961
49
49
In-frame Deletion
In-frame Deletion
MODERATE
ENST00000330387.11
COSV57791862
rs3217268
49
49
ENST00000330387.11
COSV57791862
rs3217268
CUX1
chr7
102111730
102111730
C
G
c.563C>G
tCa/tGa
p.S188*
0.436
9
1
Nonsense Mutation
Nonsense Mutation
HIGH
ENST00000292535.12
COSV105874205
9
1
ENST00000292535.12
COSV105874205
DNM2
chr19
10829156
10829156
C
T
c.2179C>T
Cat/Tat
p.H727Y
0.472
6
2
Missense Variant
Missense Variant
MODERATE
ENST00000389253.9
Conflicting_interpretations_of_pathogenicity
0.000274438000
rs142963320
6
2
ENST00000389253.9
Conflicting_interpretations_of_pathogenicity
rs142963320
EP300
chr22
41178379
41178379
A
C
c.6668A>C
cAg/cCg
p.Q2223P
0.463
22
4
Missense Variant
Missense Variant
MODERATE
ENST00000263253.9
Benign
COSV54331579
0.023220900000
rs1046088
22
4
ENST00000263253.9
Benign
COSV54331579
rs1046088
FAM135B
chr8
138153029
138153030
TG
CA
c.1445_1446inv
cCA/cTG
p.P482L
0.975
35
29
Missense Variant
Missense Variant
MODERATE
ENST00000395297.6
rs71505459
35
29
ENST00000395297.6
rs71505459
Total mutations showing: 74
F
P
1
2
3
4
5
N
E
Rows Per Page
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CNV
Histology Information for Model: BCM-15057
Patient
PDX
ER
H&E
HER2
PR
Metastasis Information for Model: BCM-15057
Patient
PDX
Abdomen
Abdominal cavity
Adrenal Gland
Anterosuperior mediastinum
Ascites
Axillary Lymph Node
Bone
Brain
CTC
Chest
Chest wall
Contralateral Breast
Fallopian tubes
Head
Hilar Node
Hip
Kidney
Leg bone
Leptomeninges
Liver
Lung
Lymph Node
Mediastinum
Metastasis Pleura
Neck
None
Other
Ovary
Pancreas
Paratracheal adenopathy
Pericardium
Peritoneal cavity
Peritoneum
Pleura
Pleural cavity
Pleural effusion
Posterior cervical nodes
Pulmonary
Retrocrural Lymph Node
SVC node
Sacral Spine
Skin
Spine
Spleen
Thymus
Patient Treatment Information for Model: BCM-15057
Event Id
Treatment
Treatment Setting
Age at Start
Age at End
Duration
Clinical Response
Pathologic Response
Reason Stopped
8
Anastrazole
Neoadjuvant
80.16
81.14
358 days
Not Reported
Not Reported
Treatment Completed
17
Paclitaxel
Adjuvant
81.25
81.51
95 days
Not Reported
Not Applicable
Treatment Completed
19
Radiation Therapy (RT)
Adjuvant
81.54
81.67
47 days
Not Reported
Not Applicable
Treatment Completed
22
Exemestane
Adjuvant
81.7
82.58
321 days
No Response (NR)
Not Applicable
Disease Progression
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