Model Details

Patient Information for Model: BCM-15057

Patient Information
Clinical Timeline

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Clinical Information at Collection
Clinical Biomarkers/Mutations at Collection
Pathology Information at Collection

Model Information for Model: BCM-15057

Model Details - Initial Implantation of Patient Tissue
Biomarkers & Mutations
Model Details - Acceptable Conditions for Passaging
Mutations (Cancer Gene Census List)

The number of models in this collection with mutations in the listed gene;
may include models that are not publicly available for distribution.
The number of models in this collection with mutations at the listed site;
may include models that are not publicly available for distribution.
GeneChrStartEndRefAltcDNA ChangeCodon ChangeProtein ChangeTVAF Gene Mutation Freq. Site Mutation Freq.Most Severe EffectAll EffectsMutation ImpactTranscript IDClinVar Clinical SignificanceCOSMIC IDgnomAD Non-Cancer AFdbSNP IDGene Mutation Freq.Site Mutation Freq.Transcript IDClinVar Clinical SignificanceCOSMIC IDdbSNP ID
ACSL3chr2222908920222908920GAc.148G>AGaa/Aaap.E50K0.45721Missense VariantMissense VariantMODERATEENST00000357430.8



21ENST00000357430.8
AKAP9chr79202286492022864AAAACc.4004_4006dupaaa/aAACaap.K1335_L1336insQ0.9745035In-frame InsertionIn-frame InsertionMODERATEENST00000356239.8

COSV62337888
rs10644111
5035ENST00000356239.8COSV62337888rs10644111
ARHGEF10chr819568821956882CAc.3654C>AgaC/gaAp.D1218E0.968101Missense VariantMissense VariantMODERATEENST00000349830.8


0.000877889000rs139515492
101ENST00000349830.8rs139515492
BARD1chr2214767531214767532CATGc.1518_1519invcaTGtg/caCAtgp.V507M0.5033424Missense VariantMissense VariantMODERATEENST00000260947.9

COSV105837301
rs386654966
3424ENST00000260947.9COSV105837301rs386654966
BRCA2chr133239478132394781CGc.9349C>GCat/Gatp.H3117D0.04211Missense VariantMissense VariantMODERATEENST00000380152.7



211ENST00000380152.7
CEBPAchr193330182533301825GGGCGGGTc.584_589dupccg/cACCCGCcgp.H195_P196dup0.44996In-frame InsertionIn-frame InsertionMODERATEENST00000498907.3

COSV57196906

96ENST00000498907.3COSV57196906
CIITAchr161090764710907647GAc.2158G>AGcc/Accp.A720T0.968851Missense VariantMissense VariantMODERATEENST00000618327.4


0.000008444590rs755306140
851ENST00000618327.4rs755306140
CIITAchr161090907010909070AGc.2702A>GcAg/cGgp.Q901R0.9848584Missense VariantMissense VariantMODERATEENST00000618327.4
Benign

0.983235000000rs7197779
8584ENST00000618327.4Benignrs7197779
CNTRLchr9121144897121144897CTc.3106C>TCtc/Ttcp.L1036F0.535101Missense VariantMissense VariantMODERATEENST00000373855.5



101ENST00000373855.5
CPEB3chr109223963592239635GAc.716C>TtCg/tTgp.S239L0.53331Missense VariantMissense VariantMODERATEENST00000265997.5


rs772631202
31ENST00000265997.5rs772631202
CREB3L2chr7137928167137928170CTGGCc.299_301delaCCAgt/agtp.T100del0.9614949In-frame DeletionIn-frame DeletionMODERATEENST00000330387.11

COSV57791862
rs3217268
4949ENST00000330387.11COSV57791862rs3217268
CUX1chr7102111730102111730CGc.563C>GtCa/tGap.S188*0.43691Nonsense MutationNonsense MutationHIGHENST00000292535.12

COSV105874205

91ENST00000292535.12COSV105874205
DNM2chr191082915610829156CTc.2179C>TCat/Tatp.H727Y0.47262Missense VariantMissense VariantMODERATEENST00000389253.9
Conflicting_interpretations_of_pathogenicity

0.000274438000rs142963320
62ENST00000389253.9Conflicting_interpretations_of_pathogenicityrs142963320
EP300chr224117837941178379ACc.6668A>CcAg/cCgp.Q2223P0.463224Missense VariantMissense VariantMODERATEENST00000263253.9
Benign
COSV54331579
0.023220900000rs1046088
224ENST00000263253.9BenignCOSV54331579rs1046088
FAM135Bchr8138153029138153030TGCAc.1445_1446invcCA/cTGp.P482L0.9753529Missense VariantMissense VariantMODERATEENST00000395297.6


rs71505459
3529ENST00000395297.6rs71505459
CNV


Histology Information for Model: BCM-15057

Patient

PDX


Metastasis Information for Model: BCM-15057
 
Patient
PDX
Abdomen
Abdominal cavity
Adrenal Gland
Anterosuperior mediastinum
Ascites
Axillary Lymph Node
Bone
Brain
CTC
Chest
Chest wall
Contralateral Breast
Fallopian tubes
Head
Hilar Node
Hip
Kidney
Leg bone
Leptomeninges
Liver
Lung
Lymph Node
Mediastinum
Metastasis Pleura
Neck
None
Other
Ovary
Pancreas
Paratracheal adenopathy
Pericardium
Peritoneal cavity
Peritoneum
Pleura
Pleural cavity
Pleural effusion
Posterior cervical nodes
Pulmonary
Retrocrural Lymph Node
SVC node
Sacral Spine
Skin
Spine
Spleen
Thymus

Patient Treatment Information for Model: BCM-15057

Event IdTreatmentTreatment SettingAge at StartAge at EndDurationClinical ResponsePathologic ResponseReason Stopped
8AnastrazoleNeoadjuvant80.1681.14358 daysNot ReportedNot ReportedTreatment Completed
17PaclitaxelAdjuvant81.2581.5195 daysNot ReportedNot ApplicableTreatment Completed
19Radiation Therapy (RT)Adjuvant81.5481.6747 daysNot ReportedNot ApplicableTreatment Completed
22ExemestaneAdjuvant81.782.58321 daysNo Response (NR)Not ApplicableDisease Progression














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