Model Details

Patient Information for Model: BCM-15051

Patient Information
Clinical Timeline

Color Keys:
 
 Positive
 
 Negative
 
 N/A

Clinical Information at Collection
Clinical Biomarkers/Mutations at Collection
Pathology Information at Collection

Model Information for Model: BCM-15051

Biomarkers & Mutations
Model Details
Mutations (Cancer Gene Census List)

The number of models in this collection with mutations in the listed gene
The number of models in this collection with mutations at the listed site
GeneChrStartEndRefAltcDNA ChangeCodon ChangeProtein ChangeTVAF Gene Mutation Freq. Site Mutation Freq.Most Severe EffectAll EffectsMutation ImpactTranscript IDClinVar Clinical SignificanceCOSMIC IDgnomAD Non-Cancer AFdbSNP IDGene Mutation Freq.Site Mutation Freq.Transcript IDClinVar Clinical SignificanceCOSMIC IDdbSNP ID
ABI1chr102674228526742285AG0.2844034Downstream Gene Variantdownstream_gene_variantMODIFIERNM_005470.3


rs10764638
4034NM_005470.3rs10764638
ABL2chr1179097772179097772TG0.667104Downstream Gene Variantdownstream_gene_variantMODIFIERNM_007314.3


rs79003648
104NM_007314.3rs79003648
ACSL6chr5131945413131945413GC0.9614718Downstream Gene Variantdownstream_gene_variantMODIFIERNM_001009185.2


rs652839
4718NM_001009185.2rs652839
ACSL6chr5131947848131947848GAG0.9314719Downstream Gene Variantdownstream_gene_variantMODIFIERNM_001009185.2


rs34365565
4719NM_001009185.2rs34365565
ACVR1chr2157737393157737393CT1.022213' UTR variant3_prime_UTR_variantMODIFIERNM_001105.4


rs2228948
2221NM_001105.4rs2228948
AFF1chr48713577387135773AG0.98180803' UTR variant3_prime_UTR_variantMODIFIERNM_001166693.2


rs342464
8080NM_001166693.2rs342464
AKT2chr194023381440233814GT0.46750473' UTR variant3_prime_UTR_variantMODIFIERNM_001626.5


rs2304186
5047NM_001626.5rs2304186
APCchr5112707585112707585CG0.9412012Intragenic Variantintragenic_variantMODIFIER


rs79896135
2012rs79896135
ARchrX6754651467546517TTGGCc.1418_1420dupGCGp.Gly473dup0.832458In-frame Insertion (Disruptive)disruptive_inframe_insertionMODERATENM_000044.3


rs760580125
458NM_000044.3rs760580125
ARHGEF10Lchr11769750217697503GGC0.9877773' UTR variant3_prime_UTR_variantMODIFIERNM_018125.3


rs3835471
7777NM_018125.3rs3835471
ARNTchr1150807005150807023TTTCTCTCTCTCTCTCTCTC0.725347Downstream Gene Variantdownstream_gene_variantMODIFIERNM_001668.3


rs146635750
347NM_001668.3rs146635750
ASXL1chr203235868532358685AG0.3244915' UTR variant5_prime_UTR_variantMODIFIERNM_015338.5



491NM_015338.5
ATICchr2215311925215311925AG0.9647974Upstream Gene Variantupstream_gene_variantMODIFIERNM_004044.6


rs78631308
7974NM_004044.6rs78631308
ATICchr2215349769215349769TG0.96279613' UTR variant3_prime_UTR_variantMODIFIERNM_004044.6

COSN19749524
rs10498036
7961NM_004044.6COSN19749524rs10498036
ATP1A1chr1116406090116406090GA1.04948Downstream Gene Variantdownstream_gene_variantMODIFIERNM_000701.7


rs850610
4948NM_000701.7rs850610
CNV


Histology Information for Model: BCM-15051

Patient

PDX

H&E

ER

PR

HER2


Metastasis Information for Model: BCM-15051
 
Patient
PDX
Abdomen
Anterosuperior mediastinum
Bone
Brain
CTC
Chest
Chest wall
Contralateral breast
Fallopian tubes
Hip
Kidney
Leg bone
Liver
Lung
Lymph Node
Mediastinum
Neck
Other
Ovary
Pancreas
Paratracheal adenopathy
Pericardium
Peritoneal cavity
Peritoneum
Pleura
Pleural Cavitiy
Pleural effusion
Posterior cervical nodes
SVC node
Skin
Thymus

Patient Treatment Information for Model: BCM-15051

Event IdTreatmentTreatment SettingAge at StartAge at EndDurationClinical ResponseReason Stopped
6[Paclitaxel, Carboplatin]Neoadjuvant59.4959.7388 daysTreatment Completed
12[Doxorubicin, Cyclophosphamide]Neoadjuvant59.859.8415 daysProgressive DiseaseDisease Progression
16[Radiation Therapy (RT)]Adjuvant60.00.0UnknownCurrent Treatment












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