Model Details

Patient Information for Model: BCM-15046

Patient Information
Clinical Timeline

Color Keys:
 
 Positive
 
 Negative
 
 N/A

Clinical Information at Collection
Clinical Biomarkers/Mutations at Collection
Pathology Information at Collection

Model Information for Model: BCM-15046

Biomarkers & Mutations
Model Details
Mutations (Cancer Gene Census List)

The number of models in this collection with mutations in the listed gene
The number of models in this collection with mutations at the listed site
GeneChrStartEndRefAltVariant TypecDNA ChangeCodon ChangeProtein ChangeTVAF Gene Mutation Freq. Site Mutation Freq.Gene Mutation Freq.Site Mutation Freq.
AKAP979172664191726644TAGATDeletionc.10369_10371delp.R3458del0.273252252
ARX6676515866765158TTGCAGCAGCAGCAInsertionc.170_171insGCAGCAGCAGCAp.Q80_E81insQQQQ0.465422422
ARID1A12702334027023340GAMissense Variantc.446G>AgGc/gAcp.G149D0.825222222
ATM11108175462108175462GAMissense Variantc.5557G>AGat/Aatp.D1853N0.94231123112
BARD12215617178215617178CGMissense Variantc.260G>CtGc/tCcp.C87S0.649183183
BAZ1A143526945435269454CGMissense Variantc.1104G>CgaG/gaCp.E368D0.143252252
BCORL1X129147241129147241CTMissense Variantc.493C>TCgg/Tggp.R165W0.1929191
BLM159132609991326099CTMissense Variantc.2603C>TcCg/cTgp.P868L0.979278278
BLM159135452191354521GAMissense Variantc.3568G>AGta/Atap.V1190I1.027112711
CASP911584471815844718GAMissense Variantc.305C>TaCc/aTcp.T102I0.878176176
CDK12173761886837618871GAGAGDeletionc.545_547delp.K183del0.9397272
CHD2159354548893545488TAMissense Variantc.4219T>ATct/Actp.S1407T0.927122122
CIC194279549242795492CTMissense Variantc.2572C>TCcc/Tccp.P858S0.94242242
CNTRL9123929920123929920GAMissense Variantc.4153G>AGaa/Aaap.E1385K0.96323323
EGFR75522925555229255GAMissense Variantc.761G>AaGg/aAgp.R254K0.20739253925
CNV


Histology Information for Model: BCM-15046

Patient

PDX

H&E

ER

PR

HER2


Metastasis Information for Model: BCM-15046
 
Patient
PDX
Abdomen
Anterosuperior mediastinum
Bone
Brain
CTC
Chest
Chest wall
Contralateral breast
Fallopian tubes
Hip
Kidney
Leg bone
Liver
Lung
Lymph Node
Mediastinum
Neck
Other
Ovary
Pancreas
Paratracheal adenopathy
Pericardium
Peritoneal cavity
Peritoneum
Pleura
Pleural Cavitiy
Pleural effusion
Posterior cervical nodes
SVC node
Skin
Thymus

Patient Treatment Information for Model: BCM-15046

Event IdTreatmentTreatment SettingAge at StartAge at EndDurationClinical ResponsePathologic ResponseReason Stopped
16[Doxorubicin, Cyclophosphamide]Neoadjuvant33.9834.0940 daysPartial ResponseNot ReportedTreatment Completed
17[Paclitaxel, Carboplatin]Neoadjuvant34.1334.3477 daysNot ReportedNot ReportedTreatment Completed
26[Radiation Therapy (RT)]Neoadjuvant34.3934.540 daysComplete ResponseTreatment Completed
27[Cisplatin]Neoadjuvant34.434.4726 daysComplete ResponseTreatment Completed
36[Capecitabine]Adjuvant34.835.3183 daysNot ReportedTreatment Completed
38[Radiation Therapy (RT)]Recurrent/Metastatic35.80.0UnknownNot ReportedTreatment Completed
42[Capecitabine]Recurrent/Metastatic35.8335.9233 daysNot ReportedDisease Progression
43[Eribulin]Recurrent/Metastatic35.9535.964 days












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