Model Details

Patient Information for Model: BCM-15046

Patient Information
Clinical Timeline

Color Keys:
 
 Positive
 
 Negative
 
 N/A

Clinical Information at Collection
Clinical Biomarkers/Mutations at Collection
Pathology Information at Collection

Model Information for Model: BCM-15046

Model Details - Initial Implantation of Patient Tissue
Biomarkers & Mutations
Model Details - Acceptable Conditions for Passaging
Mutations (Cancer Gene Census List)

The number of models in this collection with mutations in the listed gene;
may include models that are not publicly available for distribution.
The number of models in this collection with mutations at the listed site;
may include models that are not publicly available for distribution.
GeneChrStartEndRefAltcDNA ChangeCodon ChangeProtein ChangeTVAF Gene Mutation Freq. Site Mutation Freq.Most Severe EffectAll EffectsMutation ImpactTranscript IDClinVar Clinical SignificanceCOSMIC IDgnomAD Non-Cancer AFdbSNP IDGene Mutation Freq.Site Mutation Freq.Transcript IDClinVar Clinical SignificanceCOSMIC IDdbSNP ID
AKAP9chr79209732792097330TAGATc.10373_10375delAGA/-p.R3458del0.316503In-frame DeletionIn-frame DeletionMODERATEENST00000356239.8


rs757087367
503ENST00000356239.8rs757087367
ARchrX6754651467546514TTGGCc.1418_1420dup-/GGCp.G473dup0.639488In-frame InsertionIn-frame InsertionMODERATEENST00000374690.9

COSV104687717

488ENST00000374690.9COSV104687717
ARID1Achr12669684926696849GAc.446G>AgGc/gAcp.G149D0.803193Missense VariantMissense VariantMODERATEENST00000324856.13
Uncertain_significance
COSV61376273
rs2080267760
193ENST00000324856.13Uncertain_significanceCOSV61376273rs2080267760
ATRXchrX7768247177682471CGc.2785G>CGag/Cagp.E929Q0.4255956Missense VariantMissense VariantMODERATEENST00000373344.10
Benign

rs3088074
5956ENST00000373344.10Benignrs3088074
BARD1chr2214767531214767532CATGc.1518_1519invcaTGtg/caCAtgp.V507M0.6533424Missense VariantMissense VariantMODERATEENST00000260947.9

COSV105837301
rs386654966
3424ENST00000260947.9COSV105837301rs386654966
BAZ1Achr143480024834800248CGc.1104G>CgaG/gaCp.E368D0.1592Missense VariantMissense VariantMODERATEENST00000360310.6


rs1773618060
92ENST00000360310.6rs1773618060
BCL6chr3187728428187728428TGc.1472A>CcAc/cCcp.H491P0.24921Missense VariantMissense VariantMODERATEENST00000406870.7


0.000008562960rs748627517
21ENST00000406870.7rs748627517
BCORL1chrX130013265130013265CTc.493C>TCgg/Tggp.R165W0.194112Missense VariantMissense VariantMODERATEENST00000540052.5


0.000005804670rs185537912
112ENST00000540052.5rs185537912
BCRchr222318200023182000CTc.1040C>TtCt/tTtp.S347F0.10472Missense VariantMissense VariantMODERATEENST00000305877.13



72ENST00000305877.13
BCRchr222331459923314599CGc.3611C>GgCc/gGcp.A1204G0.0572Missense VariantMissense VariantMODERATEENST00000305877.13

COSV59925974
0.000060068300rs56265970
72ENST00000305877.13COSV59925974rs56265970
BIRC6chr23251547732515480ATTCAc.11059_11061delaTTCtt/attp.L3687del0.135153In-frame DeletionIn-frame DeletionMODERATEENST00000421745.6



153ENST00000421745.6
BRCA1chr174309198343091983TCc.3548A>GaAa/aGap.K1183R0.047191Missense VariantMissense VariantMODERATEENST00000357654.9
Benign
COSV58784397
0.354676000000rs16942
191ENST00000357654.9BenignCOSV58784397rs16942
CDK12chr173946261539462618GAGAGc.548_550delgAGAag/gagp.K183del0.983In-frame DeletionIn-frame DeletionMODERATEENST00000447079.6



83ENST00000447079.6
CHD2chr159299295892992958GCc.3555G>CatG/atCp.M1185I0.25451Missense VariantMissense VariantMODERATEENST00000394196.9



51ENST00000394196.9
CICchr194229134042291340CTc.2572C>TCcc/Tccp.P858S0.91113Missense VariantMissense VariantMODERATEENST00000575354.6

COSV99360636
0.000175355000rs139895527
113ENST00000575354.6COSV99360636rs139895527
CNV


Histology Information for Model: BCM-15046

Patient

PDX


Metastasis Information for Model: BCM-15046
 
Patient
PDX
Abdomen
Abdominal cavity
Adrenal Gland
Anterosuperior mediastinum
Ascites
Axillary Lymph Node
Bone
Brain
CTC
Chest
Chest wall
Contralateral Breast
Fallopian tubes
Head
Hilar Node
Hip
Kidney
Leg bone
Leptomeninges
Liver
Lung
Lymph Node
Mediastinum
Metastasis Pleura
Neck
None
Other
Ovary
Pancreas
Paratracheal adenopathy
Pericardium
Peritoneal cavity
Peritoneum
Pleura
Pleural cavity
Pleural effusion
Posterior cervical nodes
Pulmonary
Retrocrural Lymph Node
SVC node
Sacral Spine
Skin
Spine
Spleen
Thymus

Patient Treatment Information for Model: BCM-15046

Event IdTreatmentTreatment SettingAge at StartAge at EndDurationClinical ResponsePathologic ResponseReason Stopped
15Doxorubicin, CyclophosphamideNeoadjuvant33.9534.0744 daysPartial ResponseNot ApplicableTreatment Completed
20Paclitaxel, CarboplatinNeoadjuvant34.1134.3277 daysProgressive DiseaseNot ApplicableTreatment Completed
35Radiation Therapy (RT)Neoadjuvant34.3734.547 daysComplete ResponsePathological Complete Response (pCR)Treatment Completed
40CisplatinNeoadjuvant34.3834.4526 daysComplete ResponsePathological Complete Response (pCR)Treatment Completed
50CapecitabineAdjuvant34.7835.27179 daysNot ReportedNot ApplicableTreatment Completed
65Radiation Therapy (RT)Recurrent/Metastatic35.7835.8526 daysNot ReportedNot ApplicableTreatment Completed
70CapecitabineRecurrent/Metastatic35.835.9244 daysNot ReportedNot ApplicableDisease Progression
75EribulinRecurrent/Metastatic35.9335.93UnknownNot ReportedNot ApplicableDisease Progression














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