Model Details

Patient Information for Model: BCM-15046

Patient Information
Clinical Timeline

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Clinical Information at Collection
Clinical Biomarkers/Mutations at Collection
Pathology Information at Collection

Model Information for Model: BCM-15046

Biomarkers & Mutations
Model Details
Mutations (Cancer Gene Census List)

The number of models in this collection with mutations in the listed gene
The number of models in this collection with mutations at the listed site
GeneChrStartEndRefAltcDNA ChangeCodon ChangeProtein ChangeTVAF Gene Mutation Freq. Site Mutation Freq.Most Severe EffectAll EffectsMutation ImpactTranscript IDClinVar Clinical SignificanceCOSMIC IDgnomAD Non-Cancer AFdbSNP IDGene Mutation Freq.Site Mutation Freq.Transcript IDClinVar Clinical SignificanceCOSMIC IDdbSNP ID
ABI1chr102674228526742285AG0.9554034Downstream Gene Variantdownstream_gene_variantMODIFIERNM_005470.3


rs10764638
4034NM_005470.3rs10764638
ABL2chr1179097772179097772TG0.028104Downstream Gene Variantdownstream_gene_variantMODIFIERNM_007314.3


rs79003648
104NM_007314.3rs79003648
ACSL6chr5131945413131945413GC0.0584718Downstream Gene Variantdownstream_gene_variantMODIFIERNM_001009185.2


rs652839
4718NM_001009185.2rs652839
ACVR1chr2157737393157737393CT0.55422213' UTR variant3_prime_UTR_variantMODIFIERNM_001105.4


rs2228948
2221NM_001105.4rs2228948
AFF1chr48713577387135773AG0.97380803' UTR variant3_prime_UTR_variantMODIFIERNM_001166693.2


rs342464
8080NM_001166693.2rs342464
AKAP9chr79194097691940976GC0.89468645' UTR variant5_prime_UTR_variantMODIFIERNM_005751.4


rs4727267
6864NM_005751.4rs4727267
AKAP9chr79209732792097327TAGATc.10373_10375delGAAp.Arg3458del0.316683In-frame Deletion (Disruptive)disruptive_inframe_deletionMODERATENM_005751.4


0.000000000000rs757087367
683NM_005751.4rs757087367
AKT2chr194023381440233814GT0.04950473' UTR variant3_prime_UTR_variantMODIFIERNM_001626.5


rs2304186
5047NM_001626.5rs2304186
APOBEC3Bchr223898211638982116TG0.8532623Upstream Gene Variantupstream_gene_variantMODIFIERNM_004900.4


rs2267401
2623NM_004900.4rs2267401
ARchrX6754651467546517TTGGCc.1418_1420dupGCGp.Gly473dup0.639458In-frame Insertion (Disruptive)disruptive_inframe_insertionMODERATENM_000044.3


rs760580125
458NM_000044.3rs760580125
ARHGEF10Lchr11769750217697503GGC0.98777773' UTR variant3_prime_UTR_variantMODIFIERNM_018125.3


rs3835471
7777NM_018125.3rs3835471
ARID1Achr12669684926696849GAc.446G>AgGc/gAcp.Gly149Asp0.803183Missense Variantmissense_variantMODERATENM_006015.4

COSM5347041

183NM_006015.4COSM5347041
ASXL1chr203243742832437428TC0.56349433' UTR variant3_prime_UTR_variantMODIFIERNM_015338.5


rs2295763
4943NM_015338.5rs2295763
ATICchr2215311925215311925AG0.9517974Upstream Gene Variantupstream_gene_variantMODIFIERNM_004044.6


rs78631308
7974NM_004044.6rs78631308
ATICchr2215349769215349769TG0.73279613' UTR variant3_prime_UTR_variantMODIFIERNM_004044.6

COSN19749524
rs10498036
7961NM_004044.6COSN19749524rs10498036
CNV


Histology Information for Model: BCM-15046

Patient

PDX

H&E

ER

PR

HER2


Metastasis Information for Model: BCM-15046
 
Patient
PDX
Abdomen
Anterosuperior mediastinum
Bone
Brain
CTC
Chest
Chest wall
Contralateral Breast
Fallopian tubes
Hip
Kidney
Leg bone
Liver
Lung
Lymph Node
Mediastinum
Neck
Other
Ovary
Pancreas
Paratracheal adenopathy
Pericardium
Peritoneal cavity
Peritoneum
Pleura
Pleural Cavitiy
Pleural effusion
Posterior cervical nodes
SVC node
Skin
Thymus

Patient Treatment Information for Model: BCM-15046

Event IdTreatmentTreatment SettingAge at StartAge at EndDurationClinical ResponsePathologic ResponseReason Stopped
20Doxorubicin, CyclophosphamideNeoadjuvant33.9534.0744 daysPartial ResponseNot ApplicableTreatment Completed
25Paclitaxel, CarboplatinNeoadjuvant34.1134.3277 daysProgressive DiseaseNot ApplicableTreatment Completed
40Radiation Therapy (RT)Neoadjuvant34.3734.547 daysComplete ResponsePathological Complete Response (pCR)Treatment Completed
45CisplatinNeoadjuvant34.3834.4526 daysComplete ResponsePathological Complete Response (pCR)Treatment Completed
55CapecitabineAdjuvant34.7835.27179 daysNot ReportedNot ApplicableTreatment Completed
70Radiation Therapy (RT)Recurrent/Metastatic35.7835.8526 daysNot ReportedNot ApplicableTreatment Completed
75CapecitabineRecurrent/Metastatic35.835.9244 daysNot ReportedNot ApplicableDisease Progression
80EribulinRecurrent/Metastatic35.9335.93UnknownNot ReportedNot Applicable












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