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Breast
BCM-15034
Model Details
Patient
PDX Model
Histology
Metastasis
Patient Treatment
Patient Information for Model: BCM-15034
Patient Information
Clinical Timeline
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Positive
Negative
N/A
Clinical Information at Collection
Clinical Biomarkers/Mutations at Collection
Pathology Information at Collection
Model Information for Model: BCM-15034
Model Details - Initial Implantation of Patient Tissue
Biomarkers & Mutations
Model Details - Acceptable Conditions for Passaging
Mutations (Cancer Gene Census List)
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The number of models in this collection with mutations in the listed gene;
may include models that are not publicly available for distribution.
The number of models in this collection with mutations at the listed site;
may include models that are not publicly available for distribution.
Total mutations showing: 93
F
P
1
2
3
4
5
6
7
N
E
Rows Per Page
10
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Gene
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Chr
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Start
End
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cDNA Change
Codon Change
Protein Change
TVAF
Gene Mutation Freq.
Site Mutation Freq.
Most Severe Effect
All Effects
Mutation Impact
Transcript ID
ClinVar Clinical Significance
COSMIC ID
gnomAD Non-Cancer AF
dbSNP ID
Gene Mutation Freq.
Site Mutation Freq.
Transcript ID
ClinVar Clinical Significance
COSMIC ID
dbSNP ID
AKAP9
chr7
92097327
92097330
TAGA
T
c.10373_10375del
AGA/-
p.R3458del
0.082
50
3
In-frame Deletion
In-frame Deletion
MODERATE
ENST00000356239.8
rs757087367
50
3
ENST00000356239.8
rs757087367
AR
chrX
67546514
67546514
T
TGGC
c.1418_1420dup
-/GGC
p.G473dup
0.622
48
8
In-frame Insertion
In-frame Insertion
MODERATE
ENST00000374690.9
COSV104687717
48
8
ENST00000374690.9
COSV104687717
ARID1A
chr1
26696849
26696849
G
A
c.446G>A
gGc/gAc
p.G149D
0.126
19
3
Missense Variant
Missense Variant
MODERATE
ENST00000324856.13
Uncertain_significance
COSV61376273
rs2080267760
19
3
ENST00000324856.13
Uncertain_significance
COSV61376273
rs2080267760
ARID1B
chr6
157201331
157201331
G
T
c.5106G>T
aaG/aaT
p.K1702N
0.048
37
1
Missense Variant
Missense Variant
MODERATE
ENST00000636930.2
37
1
ENST00000636930.2
ATRX
chrX
77682471
77682471
C
G
c.2785G>C
Gag/Cag
p.E929Q
0.903
59
56
Missense Variant
Missense Variant
MODERATE
ENST00000373344.10
Benign
rs3088074
59
56
ENST00000373344.10
Benign
rs3088074
BARD1
chr2
214730457
214730457
T
TCATACTTTTCTTCCTGTTCA
c.1935_1954dup
gaa/gTGAACAGGAAGAAAAGTATGaa
p.E652Vfs*69
0.55
34
1
Frameshift Mutation
Frameshift Mutation
HIGH
ENST00000260947.9
34
1
ENST00000260947.9
BARD1
chr2
214797064
214797064
C
A
c.212G>T
tGt/tTt
p.C71F
0.349
34
1
Missense Variant
Missense Variant
MODERATE
ENST00000260947.9
Uncertain_significance
rs1064793959
34
1
ENST00000260947.9
Uncertain_significance
rs1064793959
BCORL1
chrX
130013265
130013265
C
T
c.493C>T
Cgg/Tgg
p.R165W
0.065
11
2
Missense Variant
Missense Variant
MODERATE
ENST00000540052.5
0.000005804670
rs185537912
11
2
ENST00000540052.5
rs185537912
BCR
chr22
23312918
23312918
G
C
c.3354G>C
gaG/gaC
p.E1118D
0.412
7
1
Missense Variant
Missense Variant
MODERATE
ENST00000305877.13
7
1
ENST00000305877.13
BIRC6
chr2
32515477
32515480
ATTC
A
c.11059_11061del
aTTCtt/att
p.L3687del
0.085
15
3
In-frame Deletion
In-frame Deletion
MODERATE
ENST00000421745.6
15
3
ENST00000421745.6
CDH17
chr8
94151968
94151968
A
T
c.1696T>A
Ttt/Att
p.F566I
0.244
6
1
Missense Variant
Missense Variant
MODERATE
ENST00000027335.8
6
1
ENST00000027335.8
CDK12
chr17
39462615
39462618
GAGA
G
c.548_550del
gAGAag/gag
p.K183del
0.064
8
3
In-frame Deletion
In-frame Deletion
MODERATE
ENST00000447079.6
8
3
ENST00000447079.6
CIC
chr19
42291340
42291340
C
T
c.2572C>T
Ccc/Tcc
p.P858S
0.098
11
3
Missense Variant
Missense Variant
MODERATE
ENST00000575354.6
COSV99360636
0.000175355000
rs139895527
11
3
ENST00000575354.6
COSV99360636
rs139895527
CIC
chr19
42292155
42292155
C
G
c.2956C>G
Ctc/Gtc
p.L986V
0.481
11
1
Missense Variant
Missense Variant
MODERATE
ENST00000575354.6
not_provided
COSV50554624
0.000562173000
rs143825601
11
1
ENST00000575354.6
not_provided
COSV50554624
rs143825601
CIITA
chr16
10909070
10909070
A
G
c.2702A>G
cAg/cGg
p.Q901R
0.974
85
84
Missense Variant
Missense Variant
MODERATE
ENST00000618327.4
Benign
0.983235000000
rs7197779
85
84
ENST00000618327.4
Benign
rs7197779
Total mutations showing: 93
F
P
1
2
3
4
5
6
7
N
E
Rows Per Page
10
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CNV
Histology Information for Model: BCM-15034
Patient
PDX
ER
HER2
PR
Metastasis Information for Model: BCM-15034
Patient
PDX
Abdomen
Abdominal cavity
Adrenal Gland
Anterosuperior mediastinum
Ascites
Axillary Lymph Node
Bone
Brain
CTC
Chest
Chest wall
Contralateral Breast
Fallopian tubes
Head
Hilar Node
Hip
Kidney
Leg bone
Leptomeninges
Liver
Lung
Lymph Node
Mediastinum
Metastasis Pleura
Neck
None
Other
Ovary
Pancreas
Paratracheal adenopathy
Pericardium
Peritoneal cavity
Peritoneum
Pleura
Pleural cavity
Pleural effusion
Posterior cervical nodes
Pulmonary
Retrocrural Lymph Node
SVC node
Sacral Spine
Skin
Spine
Spleen
Thymus
Patient Treatment Information for Model: BCM-15034
Event Id
Treatment
Treatment Setting
Age at Start
Age at End
Duration
Clinical Response
Pathologic Response
Reason Stopped
12
[Letrozole]
Adjuvant
62.99
63.04
18 days
Not Reported
Not Applicable
Side Effects
16
[Anastrozole, Palbociclib]
Recurrent/Metastatic
63.04
63.58
197 days
Not Reported
Disease Progression
22
[Paclitaxel]
Recurrent/Metastatic
63.66
64.12
168 days
Not Reported
Disease Progression
32
[Everolimus, Exemestane]
Recurrent/Metastatic
64.15
64.33
66 days
Not Reported
Disease Progression
36
[Capecitabine]
Recurrent/Metastatic
64.33
64.42
33 days
Not Reported
Disease Progression
42
[Eribulin]
Recurrent/Metastatic
64.43
64.59
58 days
Not Reported
Disease Progression
52
[Trastuzumab, Pertuzumab, Docetaxel]
Recurrent/Metastatic
64.66
65.07
150 days
Current Treatment
54
[Pertuzumab,Trastuzumab]
Recurrent/Metastatic
65.19
65.54
128 days
Not Reported
Disease Progression
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