Model Details

Patient Information for Model: BCM-15034

Patient Information
Clinical Timeline

Color Keys:
 
 Positive
 
 Negative
 
 N/A

Clinical Information at Collection
Clinical Biomarkers/Mutations at Collection
Pathology Information at Collection

Model Information for Model: BCM-15034

Model Details - Initial Implantation of Patient Tissue
Biomarkers & Mutations
Model Details - Acceptable Conditions for Passaging
Mutations (Cancer Gene Census List)

The number of models in this collection with mutations in the listed gene;
may include models that are not publicly available for distribution.
The number of models in this collection with mutations at the listed site;
may include models that are not publicly available for distribution.
GeneChrStartEndRefAltcDNA ChangeCodon ChangeProtein ChangeTVAF Gene Mutation Freq. Site Mutation Freq.Most Severe EffectAll EffectsMutation ImpactTranscript IDClinVar Clinical SignificanceCOSMIC IDgnomAD Non-Cancer AFdbSNP IDGene Mutation Freq.Site Mutation Freq.Transcript IDClinVar Clinical SignificanceCOSMIC IDdbSNP ID
AKAP9chr79209732792097330TAGATc.10373_10375delAGA/-p.R3458del0.082503In-frame DeletionIn-frame DeletionMODERATEENST00000356239.8


rs757087367
503ENST00000356239.8rs757087367
ARchrX6754651467546514TTGGCc.1418_1420dup-/GGCp.G473dup0.622488In-frame InsertionIn-frame InsertionMODERATEENST00000374690.9

COSV104687717

488ENST00000374690.9COSV104687717
ARID1Achr12669684926696849GAc.446G>AgGc/gAcp.G149D0.126193Missense VariantMissense VariantMODERATEENST00000324856.13
Uncertain_significance
COSV61376273
rs2080267760
193ENST00000324856.13Uncertain_significanceCOSV61376273rs2080267760
ARID1Bchr6157201331157201331GTc.5106G>TaaG/aaTp.K1702N0.048371Missense VariantMissense VariantMODERATEENST00000636930.2



371ENST00000636930.2
ATRXchrX7768247177682471CGc.2785G>CGag/Cagp.E929Q0.9035956Missense VariantMissense VariantMODERATEENST00000373344.10
Benign

rs3088074
5956ENST00000373344.10Benignrs3088074
BARD1chr2214730457214730457TTCATACTTTTCTTCCTGTTCAc.1935_1954dupgaa/gTGAACAGGAAGAAAAGTATGaap.E652Vfs*690.55341Frameshift MutationFrameshift MutationHIGHENST00000260947.9



341ENST00000260947.9
BARD1chr2214797064214797064CAc.212G>TtGt/tTtp.C71F0.349341Missense VariantMissense VariantMODERATEENST00000260947.9
Uncertain_significance

rs1064793959
341ENST00000260947.9Uncertain_significancers1064793959
BCORL1chrX130013265130013265CTc.493C>TCgg/Tggp.R165W0.065112Missense VariantMissense VariantMODERATEENST00000540052.5


0.000005804670rs185537912
112ENST00000540052.5rs185537912
BCRchr222331291823312918GCc.3354G>CgaG/gaCp.E1118D0.41271Missense VariantMissense VariantMODERATEENST00000305877.13



71ENST00000305877.13
BIRC6chr23251547732515480ATTCAc.11059_11061delaTTCtt/attp.L3687del0.085153In-frame DeletionIn-frame DeletionMODERATEENST00000421745.6



153ENST00000421745.6
CDH17chr89415196894151968ATc.1696T>ATtt/Attp.F566I0.24461Missense VariantMissense VariantMODERATEENST00000027335.8



61ENST00000027335.8
CDK12chr173946261539462618GAGAGc.548_550delgAGAag/gagp.K183del0.06483In-frame DeletionIn-frame DeletionMODERATEENST00000447079.6



83ENST00000447079.6
CICchr194229134042291340CTc.2572C>TCcc/Tccp.P858S0.098113Missense VariantMissense VariantMODERATEENST00000575354.6

COSV99360636
0.000175355000rs139895527
113ENST00000575354.6COSV99360636rs139895527
CICchr194229215542292155CGc.2956C>GCtc/Gtcp.L986V0.481111Missense VariantMissense VariantMODERATEENST00000575354.6
not_provided
COSV50554624
0.000562173000rs143825601
111ENST00000575354.6not_providedCOSV50554624rs143825601
CIITAchr161090907010909070AGc.2702A>GcAg/cGgp.Q901R0.9748584Missense VariantMissense VariantMODERATEENST00000618327.4
Benign

0.983235000000rs7197779
8584ENST00000618327.4Benignrs7197779
CNV


Histology Information for Model: BCM-15034

Patient

PDX


Metastasis Information for Model: BCM-15034
 
Patient
PDX
Abdomen
Abdominal cavity
Adrenal Gland
Anterosuperior mediastinum
Ascites
Axillary Lymph Node
Bone
Brain
CTC
Chest
Chest wall
Contralateral Breast
Fallopian tubes
Head
Hilar Node
Hip
Kidney
Leg bone
Leptomeninges
Liver
Lung
Lymph Node
Mediastinum
Metastasis Pleura
Neck
None
Other
Ovary
Pancreas
Paratracheal adenopathy
Pericardium
Peritoneal cavity
Peritoneum
Pleura
Pleural cavity
Pleural effusion
Posterior cervical nodes
Pulmonary
Retrocrural Lymph Node
SVC node
Sacral Spine
Skin
Spine
Spleen
Thymus

Patient Treatment Information for Model: BCM-15034

Event IdTreatmentTreatment SettingAge at StartAge at EndDurationClinical ResponsePathologic ResponseReason Stopped
12[Letrozole]Adjuvant62.9963.0418 daysNot ReportedNot ApplicableSide Effects
16[Anastrozole, Palbociclib]Recurrent/Metastatic63.0463.58197 daysNot ReportedDisease Progression
22[Paclitaxel]Recurrent/Metastatic63.6664.12168 daysNot ReportedDisease Progression
32[Everolimus, Exemestane]Recurrent/Metastatic64.1564.3366 daysNot ReportedDisease Progression
36[Capecitabine]Recurrent/Metastatic64.3364.4233 daysNot ReportedDisease Progression
42[Eribulin]Recurrent/Metastatic64.4364.5958 daysNot ReportedDisease Progression
52[Trastuzumab, Pertuzumab, Docetaxel]Recurrent/Metastatic64.6665.07150 daysCurrent Treatment
54[Pertuzumab,Trastuzumab]Recurrent/Metastatic65.1965.54128 daysNot ReportedDisease Progression














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