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Model Details

Patient Information for Model: BCM-15029

Patient Information

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Clinical Biomarkers/Mutations at Collection

Pathology Information at Collection

Model Information for Model: BCM-15029

Model Details - Initial Implantation of Patient Tissue

Biomarkers & Mutations

Model Details - Acceptable Conditions for Passaging

Mutations (Cancer Gene Census List)

GeneFilter by Gene	ChrFilter by Chr	Start	End	Ref	Alt	cDNA Change	Codon Change	Protein Change	TVAF	Gene Mutation Freq.	Site Mutation Freq.	Most Severe Effect	All Effects	Mutation Impact	Transcript ID	ClinVar Clinical Significance	COSMIC ID	gnomAD Non-Cancer AF	dbSNP ID	Gene Mutation Freq.	Site Mutation Freq.	Transcript ID	ClinVar Clinical Significance	COSMIC ID	dbSNP ID
AKAP9	chr7	92022864	92022864	A	AAAC	c.4004_4006dup	aaa/aAACaa	p.K1335_L1336insQ	0.579	50	35	In-frame Insertion	In-frame Insertion	MODERATE	ENST00000356239.8		COSV62337888		rs10644111	50	35	ENST00000356239.8		COSV62337888	rs10644111
ARID1B	chr6	157190043	157190043	G	C	c.4064G>C	aGt/aCt	p.S1355T	0.953	37	4	Missense Variant	Missense Variant	MODERATE	ENST00000636930.2		COSV104368469			37	4	ENST00000636930.2		COSV104368469
ATR	chr3	142469495	142469495	A	C	c.6394T>G	Tat/Gat	p.Y2132D	0.531	13	4	Missense Variant	Missense Variant	MODERATE	ENST00000350721.9	Benign/Likely_benign	COSV63384218	0.003051310000	rs28910273	13	4	ENST00000350721.9	Benign/Likely_benign	COSV63384218	rs28910273
BARD1	chr2	214780778	214780799	GTGGTGAAGAACATTCAGGCAA	G	c.1075_1095del	TTGCCTGAATGTTCTTCACCA/-	p.L359_P365del	0.955	34	7	In-frame Deletion	In-frame Deletion	MODERATE	ENST00000260947.9		COSV53608540		rs28997575	34	7	ENST00000260947.9		COSV53608540	rs28997575
BCL9	chr1	147619827	147619827	A	T	c.1672A>T	Agc/Tgc	p.S558C	0.454	11	1	Missense Variant	Missense Variant	MODERATE	ENST00000234739.8					11	1	ENST00000234739.8
BCLAF1	chr6	136276251	136276251	G	A	c.1274C>T	aCt/aTt	p.T425I	0.439	4	4	Missense Variant	Missense Variant	MODERATE	ENST00000531224.6				rs61757627	4	4	ENST00000531224.6			rs61757627
BCLAF1	chr6	136278195	136278195	G	A	c.686C>T	cCt/cTt	p.P229L	0.106	4	4	Missense Variant	Missense Variant	MODERATE	ENST00000531224.6		COSV104666285	0.000080251400	rs753799977	4	4	ENST00000531224.6		COSV104666285	rs753799977
CDH11	chr16	64988331	64988331	C	T	c.825G>A	atG/atA	p.M275I	0.717	6	2	Missense Variant	Missense Variant	MODERATE	ENST00000268603.9	Benign	COSV51754932	0.196252000000	rs1130821	6	2	ENST00000268603.9	Benign	COSV51754932	rs1130821
CIITA	chr16	10909070	10909070	A	G	c.2702A>G	cAg/cGg	p.Q901R	0.956	85	84	Missense Variant	Missense Variant	MODERATE	ENST00000618327.4	Benign		0.983235000000	rs7197779	85	84	ENST00000618327.4	Benign		rs7197779
CLTCL1	chr22	19234688	19234688	C	T	c.988G>A	Gag/Aag	p.E330K	0.963	19	4	Missense Variant	Missense Variant	MODERATE	ENST00000427926.6	Likely_pathogenic		0.000485627000	rs199652160	19	4	ENST00000427926.6	Likely_pathogenic		rs199652160
COL1A1	chr17	50185965	50185965	A	T	c.4061T>A	tTc/tAc	p.F1354Y	0.484	11	1	Missense Variant	Missense Variant	MODERATE	ENST00000225964.10					11	1	ENST00000225964.10
CREB3L2	chr7	137928167	137928170	CTGG	C	c.299_301del	aCCAgt/agt	p.T100del	0.938	49	49	In-frame Deletion	In-frame Deletion	MODERATE	ENST00000330387.11		COSV57791862		rs3217268	49	49	ENST00000330387.11		COSV57791862	rs3217268
ERCC2	chr19	45351661	45351661	T	G	c.2251A>C	Aag/Cag	p.K751Q	0.361	48	46	Missense Variant	Missense Variant	MODERATE	ENST00000391945.10	Benign/Likely_benign	COSV67266431	0.322955000000	rs13181	48	46	ENST00000391945.10	Benign/Likely_benign	COSV67266431	rs13181
FBXW7	chr4	152326139	152326139	A	C	c.1511T>G	gTc/gGc	p.V504G	0.983	5	4	Missense Variant	Missense Variant	MODERATE	ENST00000281708.10					5	4	ENST00000281708.10
FLT4	chr5	180603322	180603322	C	T	c.3962G>A	cGg/cAg	p.R1321Q	0.94	12	4	Missense Variant	Missense Variant	MODERATE	ENST00000261937.11	Benign/Likely_benign	COSV56126176	0.008583970000	rs79620092	12	4	ENST00000261937.11	Benign/Likely_benign	COSV56126176	rs79620092

CNV

There are no omics data for this model.

Histology Information for Model: BCM-15029

Patient

PDX

HER2