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Breast
BCM-15008
Model Details
Patient
PDX Model
Histology
Metastasis
Patient Treatment
Patient Information for Model: BCM-15008
Patient Information
Clinical Timeline
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Clinical Information at Collection
Clinical Biomarkers/Mutations at Collection
Pathology Information at Collection
Model Information for Model: BCM-15008
Biomarkers & Mutations
Model Details
Mutations (Cancer Gene Census List)
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The number of models in this collection with mutations in the listed gene
The number of models in this collection with mutations at the listed site
Total mutations showing: 291
F
P
1
2
3
4
5
6
7
8
9
10
N
E
Rows Per Page
10
15
25
50
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Gene
Filter by Gene
Chr
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Start
End
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Alt
cDNA Change
Codon Change
Protein Change
TVAF
Gene Mutation Freq.
Site Mutation Freq.
Most Severe Effect
All Effects
Mutation Impact
Transcript ID
ClinVar Clinical Significance
COSMIC ID
gnomAD Non-Cancer AF
dbSNP ID
Gene Mutation Freq.
Site Mutation Freq.
Transcript ID
ClinVar Clinical Significance
COSMIC ID
dbSNP ID
ABI1
chr10
26742285
26742285
A
G
0.892
40
34
Downstream Gene Variant
downstream_gene_variant
MODIFIER
NM_005470.3
rs10764638
40
34
NM_005470.3
rs10764638
ACSL6
chr5
131945621
131945621
G
C
0.111
47
2
Downstream Gene Variant
downstream_gene_variant
MODIFIER
NM_001009185.2
rs908013502
47
2
NM_001009185.2
rs908013502
AFF1
chr4
87135773
87135773
A
G
0.97
80
80
3' UTR variant
3_prime_UTR_variant
MODIFIER
NM_001166693.2
rs342464
80
80
NM_001166693.2
rs342464
AKAP9
chr7
91940976
91940976
G
C
0.957
68
64
5' UTR variant
5_prime_UTR_variant
MODIFIER
NM_005751.4
rs4727267
68
64
NM_005751.4
rs4727267
AKT3
chr1
243499869
243499869
C
G
0.386
15
2
3' UTR variant
3_prime_UTR_variant
MODIFIER
NM_005465.4
15
2
NM_005465.4
APC
chr5
112707585
112707585
C
G
0.887
20
12
Intragenic Variant
intragenic_variant
MODIFIER
rs79896135
20
12
rs79896135
AR
chrX
67545316
67545316
TGCAGCAGCA
T
c.231_239delGCAGCAGCA
p.Gln78_Gln80del
0.774
45
5
In-frame Deletion (Disruptive)
disruptive_inframe_deletion
MODERATE
NM_000044.3
rs797045254
45
5
NM_000044.3
rs797045254
ARHGEF10L
chr1
17697502
17697503
G
GC
0.906
77
77
3' UTR variant
3_prime_UTR_variant
MODIFIER
NM_018125.3
rs3835471
77
77
NM_018125.3
rs3835471
ARNT
chr1
150807005
150807023
T
TTCTCTCTCTCTCTCTCTC
0.478
34
7
Downstream Gene Variant
downstream_gene_variant
MODIFIER
NM_001668.3
rs146635750
34
7
NM_001668.3
rs146635750
ARNT
chr1
150876595
150876596
ACC
AC
0.262
34
3
5' UTR variant
5_prime_UTR_variant, 5_prime_UTR_variant
MODIFIER
NM_001668.3
COSN2535524
rs66776757
34
3
NM_001668.3
COSN2535524
rs66776757
ARNT
chr1
150876595
150876595
ACC
A
0.69
34
3
5' UTR variant
5_prime_UTR_variant, 5_prime_UTR_variant
MODIFIER
NM_001668.3
COSN2535524
rs66776757
34
3
NM_001668.3
COSN2535524
rs66776757
ASXL1
chr20
32437428
32437428
T
C
0.523
49
43
3' UTR variant
3_prime_UTR_variant
MODIFIER
NM_015338.5
rs2295763
49
43
NM_015338.5
rs2295763
ATIC
chr2
215311925
215311925
A
G
0.998
79
74
Upstream Gene Variant
upstream_gene_variant
MODIFIER
NM_004044.6
rs78631308
79
74
NM_004044.6
rs78631308
ATIC
chr2
215349769
215349769
T
G
0.991
79
61
3' UTR variant
3_prime_UTR_variant
MODIFIER
NM_004044.6
COSN19749524
rs10498036
79
61
NM_004044.6
COSN19749524
rs10498036
ATP1A1
chr1
116406090
116406090
G
A
0.438
49
48
Downstream Gene Variant
downstream_gene_variant
MODIFIER
NM_000701.7
rs850610
49
48
NM_000701.7
rs850610
Total mutations showing: 291
F
P
1
2
3
4
5
6
7
8
9
10
N
E
Rows Per Page
10
15
25
50
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CNV
Histology Information for Model: BCM-15008
Patient
PDX
ER
PR
HER2
Metastasis Information for Model: BCM-15008
Patient
PDX
Abdomen
Anterosuperior mediastinum
Bone
Brain
CTC
Chest
Chest wall
Contralateral breast
Fallopian tubes
Hip
Kidney
Leg bone
Liver
Lung
Lymph Node
Mediastinum
Neck
Other
Ovary
Pancreas
Paratracheal adenopathy
Pericardium
Peritoneal cavity
Peritoneum
Pleura
Pleural Cavitiy
Pleural effusion
Posterior cervical nodes
SVC node
Skin
Thymus
Patient Treatment Information for Model: BCM-15008
Event Id
Treatment
Treatment Setting
Age at Start
Age at End
Duration
Reason Stopped
12
[Doxorubicin, Cyclophosphamide]
Adjuvant
64.1
64.1
Unknown
Side Effects
14
[Docetaxel, Cyclophosphamide]
Adjuvant
64.11
64.45
124 days
Disease Progression
22
[Gemcitabine, Cisplatin]
Recurrent/Metastatic
64.54
64.54
Unknown
Disease Progression
26
[Radiation Therapy (RT), Cisplatin]
Recurrent/Metastatic
64.59
64.65
22 days
Disease Progression
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