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Patient Information for Model: BCM-15008

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Model Information for Model: BCM-15008

Biomarkers & Mutations

Model Details

Mutations (Cancer Gene Census List)

GeneFilter by Gene	ChrFilter by Chr	Start	End	Ref	Alt	cDNA Change	Protein Change	TVAF	Gene Mutation Freq.	Site Mutation Freq.	Most Severe Effect	All Effects	Mutation Impact	Transcript ID	COSMIC ID	dbSNP ID	Gene Mutation Freq.	Site Mutation Freq.	Transcript ID	COSMIC ID	dbSNP ID
ABI1	chr10	26742285	26742285	A	G			0.892	40	34	Downstream Gene Variant	downstream_gene_variant	MODIFIER	NM_005470.3		rs10764638	40	34	NM_005470.3		rs10764638
ACSL6	chr5	131945621	131945621	G	C			0.111	47	2	Downstream Gene Variant	downstream_gene_variant	MODIFIER	NM_001009185.2		rs908013502	47	2	NM_001009185.2		rs908013502
AFF1	chr4	87135773	87135773	A	G			0.97	80	80	3' UTR variant	3_prime_UTR_variant	MODIFIER	NM_001166693.2		rs342464	80	80	NM_001166693.2		rs342464
AKAP9	chr7	91940976	91940976	G	C			0.957	68	64	5' UTR variant	5_prime_UTR_variant	MODIFIER	NM_005751.4		rs4727267	68	64	NM_005751.4		rs4727267
AKT3	chr1	243499869	243499869	C	G			0.386	15	2	3' UTR variant	3_prime_UTR_variant	MODIFIER	NM_005465.4			15	2	NM_005465.4
APC	chr5	112707585	112707585	C	G			0.887	20	12	Intragenic Variant	intragenic_variant	MODIFIER			rs79896135	20	12			rs79896135
AR	chrX	67545316	67545316	TGCAGCAGCA	T	c.231_239delGCAGCAGCA	p.Gln78_Gln80del	0.774	45	5	In-frame Deletion (Disruptive)	disruptive_inframe_deletion	MODERATE	NM_000044.3		rs797045254	45	5	NM_000044.3		rs797045254
ARHGEF10L	chr1	17697502	17697503	G	GC			0.906	77	77	3' UTR variant	3_prime_UTR_variant	MODIFIER	NM_018125.3		rs3835471	77	77	NM_018125.3		rs3835471
ARNT	chr1	150807005	150807023	T	TTCTCTCTCTCTCTCTCTC			0.478	34	7	Downstream Gene Variant	downstream_gene_variant	MODIFIER	NM_001668.3		rs146635750	34	7	NM_001668.3		rs146635750
ARNT	chr1	150876595	150876596	ACC	AC			0.262	34	3	5' UTR variant	5_prime_UTR_variant, 5_prime_UTR_variant	MODIFIER	NM_001668.3	COSN2535524	rs66776757	34	3	NM_001668.3	COSN2535524	rs66776757
ARNT	chr1	150876595	150876595	ACC	A			0.69	34	3	5' UTR variant	5_prime_UTR_variant, 5_prime_UTR_variant	MODIFIER	NM_001668.3	COSN2535524	rs66776757	34	3	NM_001668.3	COSN2535524	rs66776757
ASXL1	chr20	32437428	32437428	T	C			0.523	49	43	3' UTR variant	3_prime_UTR_variant	MODIFIER	NM_015338.5		rs2295763	49	43	NM_015338.5		rs2295763
ATIC	chr2	215311925	215311925	A	G			0.998	79	74	Upstream Gene Variant	upstream_gene_variant	MODIFIER	NM_004044.6		rs78631308	79	74	NM_004044.6		rs78631308
ATIC	chr2	215349769	215349769	T	G			0.991	79	61	3' UTR variant	3_prime_UTR_variant	MODIFIER	NM_004044.6	COSN19749524	rs10498036	79	61	NM_004044.6	COSN19749524	rs10498036
ATP1A1	chr1	116406090	116406090	G	A			0.438	49	48	Downstream Gene Variant	downstream_gene_variant	MODIFIER	NM_000701.7		rs850610	49	48	NM_000701.7		rs850610

CNV

Histology Information for Model: BCM-15008

Patient

PDX

ER

PR

HER2

Metastasis Information for Model: BCM-15008

Patient

PDX

Abdomen

Anterosuperior mediastinum

Bone

Brain

CTC

Chest

Chest wall

Contralateral breast

Fallopian tubes

Hip

Kidney

Leg bone

Liver

Lung

Lymph Node

Mediastinum

Neck

Other

Ovary

Pancreas

Paratracheal adenopathy

Pericardium

Peritoneal cavity

Peritoneum

Pleura

Pleural Cavitiy

Pleural effusion

Posterior cervical nodes

SVC node

Skin

Thymus

Patient Treatment Information for Model: BCM-15008

Event Id	Treatment	Treatment Setting	Age at Start	Age at End	Duration	Reason Stopped
12	[Doxorubicin, Cyclophosphamide]	Adjuvant	64.1	64.1	Unknown	Side Effects
14	[Docetaxel, Cyclophosphamide]	Adjuvant	64.11	64.45	124 days	Disease Progression
22	[Gemcitabine, Cisplatin]	Recurrent/Metastatic	64.54	64.54	Unknown	Disease Progression
26	[Radiation Therapy (RT), Cisplatin]	Recurrent/Metastatic	64.59	64.65	22 days	Disease Progression