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Model Details

Patient Information for Model: BCM-15006

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Model Information for Model: BCM-15006

Biomarkers & Mutations

Model Details

Mutations

GeneFilter by Gene	ChrFilter by Chr	Start	End	Ref	Alt	Variant TypeFilter by Variant Type	cDNA Change	Codon Change	Protein Change	TVAF	COSMIC ID	Gene Mutation Freq.	Site Mutation Freq.
ABCB8	7	150742308	150742308	G	A	Missense Variant	c.1954G>A	c.(1954-1956)Gaa>Aaa	p.E652K	0.204		1	1
ABCB8	7	150725634	150725634	G	A	Missense Variant	c.32G>A	c.(31-33)cGg>cAg	p.R11Q	0.114		1	1
ABCC9	12	21997749	21997749	T	A	Missense Variant	c.3197A>T	c.(3196-3198)aAa>aTa	p.K1066I	0.118		2	1
AC104809.3	2	241870430	241870430	C	T	Missense Variant	c.433C>T	c.(433-435)Cgg>Tgg	p.R145W	0.505		5	1
ACAN	15	89400023	89400023	A	G	Missense Variant	c.4207A>G	c.(4207-4209)Act>Gct	p.T1403A	0.973		20	15
ACVR1	2	158622458	158622461	ATTC	A	In-frame Deletion	c.1038_1040delGAA	c.(1036-1041)aagaat>aat	p.K346del	0.231		2	1
ANLN	7	36459911	36459914	ATCT	A	In-frame Deletion	c.2004_2006delTCT	c.(2002-2007)gatctt>gat	p.L670del	0.229		2	1
ARHGAP40	20	37272422	37272422	G	A	Missense Variant	c.1279G>A	c.(1279-1281)Gtg>Atg	p.V427M	0.381		2	1
ARID1A	1	27023340	27023340	G	A	Missense Variant	c.446G>A	c.(445-447)gGc>gAc	p.G149D	0.958	COSM5347041	9	1
ASIC5	4	156787351	156787354	ATAC	A	In-frame Deletion	c.25_27delGTA	c.(25-27)gtadel	p.V9del	0.356		1	1
ATP5S	14	50790799	50790803	CACAG	C	Frame-shift Deletion	c.499_502delACAG	c.(499-504)acagacfs	p.TD167fs	0.857		1	1
BIRC6	2	32740544	32740547	ATTC	A	In-frame Deletion	c.11057_11059delTTC	c.(11056-11061)attctt>att	p.L3687del	0.158		4	1
BTBD7	14	93712185	93712185	A	ATGCTGC	In-frame Insertion	c.2569_2569insGCAGCA	c.(2569-2571)tct>GCAGCAtct	p.856_857insAA	1.0		1	1
C4orf40	4	71024425	71024485	CCCTGTTGCAGCTGAGCCTGCTGCAGAGGCACCTGTTGGAGCTGAGCCTGCTGCAGAGGCA	C	In-frame Deletion	c.457_516delCCTGTTGCAGCTGAGCCTGCTGCAGAGGCACCTGTTGGAGCTGAGCCTGCTGCAGAGGCA	c.(457-516)cctgttgcagctgagcctgctgcagaggcacctgttggagctgagcctgctgcagaggcadel	p.PVAAEPAAEAPVGAEPAAEA153del	0.758		2	2
C6orf57	6	71276706	71276706	A	C	Splice Site	c.63A>C	c.(61-63)gcA>gcC	p.A21A	0.554		1	1

CNV

Histology Information for Model: BCM-15006

Patient

PDX

H&E

ER

PR

HER2

Metastasis Information for Model: BCM-15006

Patient

PDX

Abdomen

Anterosuperior mediastinum

Bone

Brain

CTC

Chest

Chest wall

Contralateral breast

Fallopian tubes

Hip

Kidney

Leg bone

Liver

Lung

Lymph Node

Mediastinum

Neck

Other

Ovary

Pancreas

Paratracheal adenopathy

Pericardium

Peritoneal cavity

Peritoneum

Pleura

Pleural Cavitiy

Pleural effusion

Posterior cervical nodes

SVC node

Skin

Thymus

Patient Treatment Information for Model: BCM-15006

Event Id	Treatment	Treatment Setting	Age at Start	Age at End	Duration	Clinical Response	Pathologic Response	Reason Stopped
114	[Doxorubicin, Cyclophosphamide]	Neoadjuvant	33.98	34.09	40 days	Partial Response	Not Reported	Treatment Completed
118	[Paclitaxel, Carboplatin]	Neoadjuvant	34.13	34.34	77 days	Not Reported	Not Reported	Treatment Completed
121	[Radiation Therapy (RT)]	Neoadjuvant	34.39	34.5	40 days	Complete Response		Treatment Completed
122	[Cisplatin]	Neoadjuvant	34.4	34.47	26 days	Complete Response		Treatment Completed
140	[Capecitabine]	Adjuvant	34.8	35.3	183 days	Not Reported		Treatment Completed
330	[Radiation Therapy (RT)]	Recurrent/Metastatic	35.8	0.0	Unknown	Not Reported		Treatment Completed
335	[Capecitabine]	Recurrent/Metastatic	35.83	35.92	33 days	Not Reported		Disease Progression
345	[Eribulin]	Recurrent/Metastatic	35.95	35.96	4 days