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Breast
BCM-15006
Model Details
Patient
PDX Model
Histology
Metastasis
Patient Treatment
Patient Information for Model: BCM-15006
Patient Information
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Clinical Information at Collection
Clinical Biomarkers/Mutations at Collection
Pathology Information at Collection
Model Information for Model: BCM-15006
Biomarkers & Mutations
Model Details
Mutations (Cancer Gene Census List)
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The number of models in this collection with mutations in the listed gene
The number of models in this collection with mutations at the listed site
Total mutations showing: 269
F
P
1
2
3
4
5
6
7
8
9
10
N
E
Rows Per Page
10
15
25
50
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Gene
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Chr
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Start
End
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cDNA Change
Codon Change
Protein Change
TVAF
Gene Mutation Freq.
Site Mutation Freq.
Most Severe Effect
All Effects
Mutation Impact
Transcript ID
ClinVar Clinical Significance
COSMIC ID
gnomAD Non-Cancer AF
dbSNP ID
Gene Mutation Freq.
Site Mutation Freq.
Transcript ID
ClinVar Clinical Significance
COSMIC ID
dbSNP ID
ABI1
chr10
26742285
26742285
A
G
0.999
40
34
Downstream Gene Variant
downstream_gene_variant
MODIFIER
NM_005470.3
rs10764638
40
34
NM_005470.3
rs10764638
ACVR1
chr2
157737393
157737393
C
T
0.812
22
21
3' UTR variant
3_prime_UTR_variant
MODIFIER
NM_001105.4
rs2228948
22
21
NM_001105.4
rs2228948
ACVR1
chr2
157765946
157765946
ATTC
A
c.1038_1040delGAA
p.Lys346del
0.26
22
1
In-frame Deletion (Disruptive)
disruptive_inframe_deletion
MODERATE
NM_001105.4
22
1
NM_001105.4
AFF1
chr4
87135773
87135773
A
G
0.999
80
80
3' UTR variant
3_prime_UTR_variant
MODIFIER
NM_001166693.2
rs342464
80
80
NM_001166693.2
rs342464
AKAP9
chr7
91940976
91940976
G
C
0.924
68
64
5' UTR variant
5_prime_UTR_variant
MODIFIER
NM_005751.4
rs4727267
68
64
NM_005751.4
rs4727267
AKAP9
chr7
92097327
92097327
TAGA
T
c.10373_10375delGAA
p.Arg3458del
0.184
68
3
In-frame Deletion (Disruptive)
disruptive_inframe_deletion
MODERATE
NM_005751.4
0.000000000000
rs757087367
68
3
NM_005751.4
rs757087367
APOBEC3B
chr22
38982116
38982116
T
G
0.999
26
23
Upstream Gene Variant
upstream_gene_variant
MODIFIER
NM_004900.4
rs2267401
26
23
NM_004900.4
rs2267401
ARHGEF10L
chr1
17697502
17697503
G
GC
1.0
77
77
3' UTR variant
3_prime_UTR_variant
MODIFIER
NM_018125.3
rs3835471
77
77
NM_018125.3
rs3835471
ARID1A
chr1
26696849
26696849
G
A
c.446G>A
gGc/gAc
p.Gly149Asp
0.861
18
3
Missense Variant
missense_variant
MODERATE
NM_006015.4
COSM5347041
18
3
NM_006015.4
COSM5347041
ASXL1
chr20
32437428
32437428
T
C
0.714
49
43
3' UTR variant
3_prime_UTR_variant
MODIFIER
NM_015338.5
rs2295763
49
43
NM_015338.5
rs2295763
ATIC
chr2
215311925
215311925
A
G
0.982
79
74
Upstream Gene Variant
upstream_gene_variant
MODIFIER
NM_004044.6
rs78631308
79
74
NM_004044.6
rs78631308
ATP1A1
chr1
116406090
116406090
G
A
1.0
49
48
Downstream Gene Variant
downstream_gene_variant
MODIFIER
NM_000701.7
rs850610
49
48
NM_000701.7
rs850610
ATRX
chrX
77682471
77682471
C
G
c.2785G>C
Gag/Cag
p.Glu929Gln
0.233
54
52
Missense Variant
missense_variant
MODERATE
NM_000489.4
rs3088074
54
52
NM_000489.4
rs3088074
AXIN1
chr16
287017
287017
G
A
0.365
62
25
Downstream Gene Variant
downstream_gene_variant
MODIFIER
NM_003502.3
COSN6645580
rs449401
62
25
NM_003502.3
COSN6645580
rs449401
B2M
chr15
44711166
44711166
T
G
0.999
48
45
Upstream Gene Variant
upstream_gene_variant
MODIFIER
NM_004048.2
COSN15632065
rs2255235
48
45
NM_004048.2
COSN15632065
rs2255235
Total mutations showing: 269
F
P
1
2
3
4
5
6
7
8
9
10
N
E
Rows Per Page
10
15
25
50
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CNV
Histology Information for Model: BCM-15006
Patient
PDX
H&E
ER
PR
HER2
Metastasis Information for Model: BCM-15006
Patient
PDX
Abdomen
Anterosuperior mediastinum
Bone
Brain
CTC
Chest
Chest wall
Contralateral breast
Fallopian tubes
Hip
Kidney
Leg bone
Liver
Lung
Lymph Node
Mediastinum
Neck
Other
Ovary
Pancreas
Paratracheal adenopathy
Pericardium
Peritoneal cavity
Peritoneum
Pleura
Pleural Cavitiy
Pleural effusion
Posterior cervical nodes
SVC node
Skin
Thymus
Patient Treatment Information for Model: BCM-15006
Event Id
Treatment
Treatment Setting
Age at Start
Age at End
Duration
Clinical Response
Pathologic Response
Reason Stopped
16
[Doxorubicin, Cyclophosphamide]
Neoadjuvant
33.98
34.09
40 days
Partial Response
Not Reported
Treatment Completed
17
[Paclitaxel, Carboplatin]
Neoadjuvant
34.13
34.34
77 days
Not Reported
Not Reported
Treatment Completed
26
[Radiation Therapy (RT)]
Neoadjuvant
34.39
34.5
40 days
Complete Response
Treatment Completed
27
[Cisplatin]
Neoadjuvant
34.4
34.47
26 days
Complete Response
Treatment Completed
36
[Capecitabine]
Adjuvant
34.8
35.3
183 days
Not Reported
Treatment Completed
38
[Radiation Therapy (RT)]
Recurrent/Metastatic
35.8
0.0
Unknown
Not Reported
Treatment Completed
42
[Capecitabine]
Recurrent/Metastatic
35.83
35.92
33 days
Not Reported
Disease Progression
43
[Eribulin]
Recurrent/Metastatic
35.95
35.96
4 days
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