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Model Details

Patient Information for Model: BCM-15006

Patient Information

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Clinical Information at Collection

Clinical Biomarkers/Mutations at Collection

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Model Information for Model: BCM-15006

Biomarkers & Mutations

Model Details

Mutations (Cancer Gene Census List)

GeneFilter by Gene	ChrFilter by Chr	Start	End	Ref	Alt	cDNA Change	Codon Change	Protein Change	TVAF	Gene Mutation Freq.	Site Mutation Freq.	Most Severe Effect	All Effects	Mutation Impact	Transcript ID	COSMIC ID	gnomAD Non-Cancer AF	dbSNP ID	Gene Mutation Freq.	Site Mutation Freq.	Transcript ID	COSMIC ID	dbSNP ID
ABI1	chr10	26742285	26742285	A	G				0.999	40	34	Downstream Gene Variant	downstream_gene_variant	MODIFIER	NM_005470.3			rs10764638	40	34	NM_005470.3		rs10764638
ACVR1	chr2	157737393	157737393	C	T				0.812	22	21	3' UTR variant	3_prime_UTR_variant	MODIFIER	NM_001105.4			rs2228948	22	21	NM_001105.4		rs2228948
ACVR1	chr2	157765946	157765946	ATTC	A	c.1038_1040delGAA		p.Lys346del	0.26	22	1	In-frame Deletion (Disruptive)	disruptive_inframe_deletion	MODERATE	NM_001105.4				22	1	NM_001105.4
AFF1	chr4	87135773	87135773	A	G				0.999	80	80	3' UTR variant	3_prime_UTR_variant	MODIFIER	NM_001166693.2			rs342464	80	80	NM_001166693.2		rs342464
AKAP9	chr7	91940976	91940976	G	C				0.924	68	64	5' UTR variant	5_prime_UTR_variant	MODIFIER	NM_005751.4			rs4727267	68	64	NM_005751.4		rs4727267
AKAP9	chr7	92097327	92097327	TAGA	T	c.10373_10375delGAA		p.Arg3458del	0.184	68	3	In-frame Deletion (Disruptive)	disruptive_inframe_deletion	MODERATE	NM_005751.4		0.000000000000	rs757087367	68	3	NM_005751.4		rs757087367
APOBEC3B	chr22	38982116	38982116	T	G				0.999	26	23	Upstream Gene Variant	upstream_gene_variant	MODIFIER	NM_004900.4			rs2267401	26	23	NM_004900.4		rs2267401
ARHGEF10L	chr1	17697502	17697503	G	GC				1.0	77	77	3' UTR variant	3_prime_UTR_variant	MODIFIER	NM_018125.3			rs3835471	77	77	NM_018125.3		rs3835471
ARID1A	chr1	26696849	26696849	G	A	c.446G>A	gGc/gAc	p.Gly149Asp	0.861	18	3	Missense Variant	missense_variant	MODERATE	NM_006015.4	COSM5347041			18	3	NM_006015.4	COSM5347041
ASXL1	chr20	32437428	32437428	T	C				0.714	49	43	3' UTR variant	3_prime_UTR_variant	MODIFIER	NM_015338.5			rs2295763	49	43	NM_015338.5		rs2295763
ATIC	chr2	215311925	215311925	A	G				0.982	79	74	Upstream Gene Variant	upstream_gene_variant	MODIFIER	NM_004044.6			rs78631308	79	74	NM_004044.6		rs78631308
ATP1A1	chr1	116406090	116406090	G	A				1.0	49	48	Downstream Gene Variant	downstream_gene_variant	MODIFIER	NM_000701.7			rs850610	49	48	NM_000701.7		rs850610
ATRX	chrX	77682471	77682471	C	G	c.2785G>C	Gag/Cag	p.Glu929Gln	0.233	54	52	Missense Variant	missense_variant	MODERATE	NM_000489.4			rs3088074	54	52	NM_000489.4		rs3088074
AXIN1	chr16	287017	287017	G	A				0.365	62	25	Downstream Gene Variant	downstream_gene_variant	MODIFIER	NM_003502.3	COSN6645580		rs449401	62	25	NM_003502.3	COSN6645580	rs449401
B2M	chr15	44711166	44711166	T	G				0.999	48	45	Upstream Gene Variant	upstream_gene_variant	MODIFIER	NM_004048.2	COSN15632065		rs2255235	48	45	NM_004048.2	COSN15632065	rs2255235

CNV

Histology Information for Model: BCM-15006

Patient

PDX

H&E

ER

PR

HER2

Metastasis Information for Model: BCM-15006

Patient

PDX

Abdomen

Anterosuperior mediastinum

Bone

Brain

CTC

Chest

Chest wall

Contralateral breast

Fallopian tubes

Hip

Kidney

Leg bone

Liver

Lung

Lymph Node

Mediastinum

Neck

Other

Ovary

Pancreas

Paratracheal adenopathy

Pericardium

Peritoneal cavity

Peritoneum

Pleura

Pleural Cavitiy

Pleural effusion

Posterior cervical nodes

SVC node

Skin

Thymus

Patient Treatment Information for Model: BCM-15006

Event Id	Treatment	Treatment Setting	Age at Start	Age at End	Duration	Clinical Response	Pathologic Response	Reason Stopped
16	[Doxorubicin, Cyclophosphamide]	Neoadjuvant	33.98	34.09	40 days	Partial Response	Not Reported	Treatment Completed
17	[Paclitaxel, Carboplatin]	Neoadjuvant	34.13	34.34	77 days	Not Reported	Not Reported	Treatment Completed
26	[Radiation Therapy (RT)]	Neoadjuvant	34.39	34.5	40 days	Complete Response		Treatment Completed
27	[Cisplatin]	Neoadjuvant	34.4	34.47	26 days	Complete Response		Treatment Completed
36	[Capecitabine]	Adjuvant	34.8	35.3	183 days	Not Reported		Treatment Completed
38	[Radiation Therapy (RT)]	Recurrent/Metastatic	35.8	0.0	Unknown	Not Reported		Treatment Completed
42	[Capecitabine]	Recurrent/Metastatic	35.83	35.92	33 days	Not Reported		Disease Progression
43	[Eribulin]	Recurrent/Metastatic	35.95	35.96	4 days