Model Details

Patient Information for Model: BCM-15006

Patient Information
Clinical Timeline

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Clinical Information at Collection
Clinical Biomarkers/Mutations at Collection
Pathology Information at Collection

Model Information for Model: BCM-15006

Biomarkers & Mutations
Model Details
Mutations (Cancer Gene Census List)

The number of models in this collection with mutations in the listed gene
The number of models in this collection with mutations at the listed site
GeneChrStartEndRefAltcDNA ChangeCodon ChangeProtein ChangeTVAF Gene Mutation Freq. Site Mutation Freq.Most Severe EffectAll EffectsMutation ImpactTranscript IDClinVar Clinical SignificanceCOSMIC IDgnomAD Non-Cancer AFdbSNP IDGene Mutation Freq.Site Mutation Freq.Transcript IDClinVar Clinical SignificanceCOSMIC IDdbSNP ID
ABI1chr102674228526742285AG0.9994034Downstream Gene Variantdownstream_gene_variantMODIFIERNM_005470.3


rs10764638
4034NM_005470.3rs10764638
ACVR1chr2157737393157737393CT0.81222213' UTR variant3_prime_UTR_variantMODIFIERNM_001105.4


rs2228948
2221NM_001105.4rs2228948
ACVR1chr2157765946157765946ATTCAc.1038_1040delGAAp.Lys346del0.26221In-frame Deletion (Disruptive)disruptive_inframe_deletionMODERATENM_001105.4



221NM_001105.4
AFF1chr48713577387135773AG0.99980803' UTR variant3_prime_UTR_variantMODIFIERNM_001166693.2


rs342464
8080NM_001166693.2rs342464
AKAP9chr79194097691940976GC0.92468645' UTR variant5_prime_UTR_variantMODIFIERNM_005751.4


rs4727267
6864NM_005751.4rs4727267
AKAP9chr79209732792097327TAGATc.10373_10375delGAAp.Arg3458del0.184683In-frame Deletion (Disruptive)disruptive_inframe_deletionMODERATENM_005751.4


0.000000000000rs757087367
683NM_005751.4rs757087367
APOBEC3Bchr223898211638982116TG0.9992623Upstream Gene Variantupstream_gene_variantMODIFIERNM_004900.4


rs2267401
2623NM_004900.4rs2267401
ARHGEF10Lchr11769750217697503GGC1.077773' UTR variant3_prime_UTR_variantMODIFIERNM_018125.3


rs3835471
7777NM_018125.3rs3835471
ARID1Achr12669684926696849GAc.446G>AgGc/gAcp.Gly149Asp0.861183Missense Variantmissense_variantMODERATENM_006015.4

COSM5347041

183NM_006015.4COSM5347041
ASXL1chr203243742832437428TC0.71449433' UTR variant3_prime_UTR_variantMODIFIERNM_015338.5


rs2295763
4943NM_015338.5rs2295763
ATICchr2215311925215311925AG0.9827974Upstream Gene Variantupstream_gene_variantMODIFIERNM_004044.6


rs78631308
7974NM_004044.6rs78631308
ATP1A1chr1116406090116406090GA1.04948Downstream Gene Variantdownstream_gene_variantMODIFIERNM_000701.7


rs850610
4948NM_000701.7rs850610
ATRXchrX7768247177682471CGc.2785G>CGag/Cagp.Glu929Gln0.2335452Missense Variantmissense_variantMODERATENM_000489.4


rs3088074
5452NM_000489.4rs3088074
AXIN1chr16287017287017GA0.3656225Downstream Gene Variantdownstream_gene_variantMODIFIERNM_003502.3

COSN6645580
rs449401
6225NM_003502.3COSN6645580rs449401
B2Mchr154471116644711166TG0.9994845Upstream Gene Variantupstream_gene_variantMODIFIERNM_004048.2

COSN15632065
rs2255235
4845NM_004048.2COSN15632065rs2255235
CNV


Histology Information for Model: BCM-15006

Patient

PDX

H&E

ER

PR

HER2


Metastasis Information for Model: BCM-15006
 
Patient
PDX
Abdomen
Anterosuperior mediastinum
Bone
Brain
CTC
Chest
Chest wall
Contralateral Breast
Fallopian tubes
Hip
Kidney
Leg bone
Liver
Lung
Lymph Node
Mediastinum
Neck
Other
Ovary
Pancreas
Paratracheal adenopathy
Pericardium
Peritoneal cavity
Peritoneum
Pleura
Pleural Cavitiy
Pleural effusion
Posterior cervical nodes
SVC node
Skin
Thymus

Patient Treatment Information for Model: BCM-15006

Event IdTreatmentTreatment SettingAge at StartAge at EndDurationClinical ResponsePathologic ResponseReason Stopped
20Doxorubicin, CyclophosphamideNeoadjuvant33.9534.0744 daysPartial ResponseNot ApplicableTreatment Completed
25Paclitaxel, CarboplatinNeoadjuvant34.1134.3277 daysProgressive DiseaseNot ApplicableTreatment Completed
40Radiation Therapy (RT)Neoadjuvant34.3734.547 daysComplete ResponsePathological Complete Response (pCR)Treatment Completed
45CisplatinNeoadjuvant34.3834.4526 daysComplete ResponsePathological Complete Response (pCR)Treatment Completed
55CapecitabineAdjuvant34.7835.27179 daysNot ReportedNot ApplicableTreatment Completed
70Radiation Therapy (RT)Recurrent/Metastatic35.7835.8526 daysNot ReportedNot ApplicableTreatment Completed
75CapecitabineRecurrent/Metastatic35.835.9244 daysNot ReportedNot ApplicableDisease Progression
80EribulinRecurrent/Metastatic35.9335.93UnknownNot ReportedNot Applicable












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