Model Details

Patient Information for Model: BCM-15006

Patient Information
Clinical Timeline

Color Keys:
 
 Positive
 
 Negative
 
 N/A

Clinical Information at Collection
Clinical Biomarkers/Mutations at Collection
Pathology Information at Collection

Model Information for Model: BCM-15006

Model Details - Initial Implantation of Patient Tissue
Biomarkers & Mutations
Model Details - Acceptable Conditions for Passaging
Mutations (Cancer Gene Census List)

The number of models in this collection with mutations in the listed gene;
may include models that are not publicly available for distribution.
The number of models in this collection with mutations at the listed site;
may include models that are not publicly available for distribution.
GeneChrStartEndRefAltcDNA ChangeCodon ChangeProtein ChangeTVAF Gene Mutation Freq. Site Mutation Freq.Most Severe EffectAll EffectsMutation ImpactTranscript IDClinVar Clinical SignificanceCOSMIC IDgnomAD Non-Cancer AFdbSNP IDGene Mutation Freq.Site Mutation Freq.Transcript IDClinVar Clinical SignificanceCOSMIC IDdbSNP ID
ACVR1chr2157765946157765949ATTCAc.1038_1040delaaGAAt/aatp.K346del0.2621In-frame DeletionIn-frame DeletionMODERATEENST00000434821.7



21ENST00000434821.7
AKAP9chr79209732792097330TAGATc.10373_10375delAGA/-p.R3458del0.184503In-frame DeletionIn-frame DeletionMODERATEENST00000356239.8


rs757087367
503ENST00000356239.8rs757087367
ARID1Achr12669684926696849GAc.446G>AgGc/gAcp.G149D0.861193Missense VariantMissense VariantMODERATEENST00000324856.13
Uncertain_significance
COSV61376273
rs2080267760
193ENST00000324856.13Uncertain_significanceCOSV61376273rs2080267760
ATRXchrX7768247177682471CGc.2785G>CGag/Cagp.E929Q0.2335956Missense VariantMissense VariantMODERATEENST00000373344.10
Benign

rs3088074
5956ENST00000373344.10Benignrs3088074
BARD1chr2214767531214767532CATGc.1518_1519invcaTGtg/caCAtgp.V507M0.4863424Missense VariantMissense VariantMODERATEENST00000260947.9

COSV105837301
rs386654966
3424ENST00000260947.9COSV105837301rs386654966
BCRchr222331459923314599CGc.3611C>GgCc/gGcp.A1204G0.17572Missense VariantMissense VariantMODERATEENST00000305877.13

COSV59925974
0.000060068300rs56265970
72ENST00000305877.13COSV59925974rs56265970
BIRC6chr23251547732515480ATTCAc.11059_11061delaTTCtt/attp.L3687del0.211153In-frame DeletionIn-frame DeletionMODERATEENST00000421745.6



153ENST00000421745.6
CDK12chr173946261539462618GAGAGc.548_550delgAGAag/gagp.K183del0.98283In-frame DeletionIn-frame DeletionMODERATEENST00000447079.6



83ENST00000447079.6
CICchr194229134042291340CTc.2572C>TCcc/Tccp.P858S0.97113Missense VariantMissense VariantMODERATEENST00000575354.6

COSV99360636
0.000175355000rs139895527
113ENST00000575354.6COSV99360636rs139895527
CIITAchr161090907010909070AGc.2702A>GcAg/cGgp.Q901R0.968584Missense VariantMissense VariantMODERATEENST00000618327.4
Benign

0.983235000000rs7197779
8584ENST00000618327.4Benignrs7197779
CREB3L2chr7137928167137928170CTGGCc.299_301delaCCAgt/agtp.T100del0.8554949In-frame DeletionIn-frame DeletionMODERATEENST00000330387.11

COSV57791862
rs3217268
4949ENST00000330387.11COSV57791862rs3217268
ERBB3chr125610121456101214ATc.3355A>TAgc/Tgcp.S1119C0.95149Missense VariantMissense VariantMODERATEENST00000267101.8
Benign
COSV57247854
0.088057000000rs773123
149ENST00000267101.8BenignCOSV57247854rs773123
ERCC5chr13102846322102846322CTc.56C>TcCc/cTcp.P19L0.954143Missense VariantMissense VariantMODERATEENST00000652225.2
Uncertain_significance
COSV99053842
0.000582552000rs34291397
143ENST00000652225.2Uncertain_significanceCOSV99053842rs34291397
ERCC5chr13102862407102862407CTc.1258C>TCgt/Tgtp.R420C0.317143Missense VariantMissense VariantMODERATEENST00000652225.2


0.000012670500rs374911899
143ENST00000652225.2rs374911899
FAM135Bchr8138153029138153030TGCAc.1445_1446invcCA/cTGp.P482L0.6573529Missense VariantMissense VariantMODERATEENST00000395297.6


rs71505459
3529ENST00000395297.6rs71505459
CNV


Histology Information for Model: BCM-15006

Patient

PDX


Metastasis Information for Model: BCM-15006
 
Patient
PDX
Abdomen
Abdominal cavity
Adrenal Gland
Anterosuperior mediastinum
Ascites
Axillary Lymph Node
Bone
Brain
CTC
Chest
Chest wall
Contralateral Breast
Fallopian tubes
Head
Hilar Node
Hip
Kidney
Leg bone
Leptomeninges
Liver
Lung
Lymph Node
Mediastinum
Metastasis Pleura
Neck
None
Other
Ovary
Pancreas
Paratracheal adenopathy
Pericardium
Peritoneal cavity
Peritoneum
Pleura
Pleural cavity
Pleural effusion
Posterior cervical nodes
Pulmonary
Retrocrural Lymph Node
SVC node
Sacral Spine
Skin
Spine
Spleen
Thymus

Patient Treatment Information for Model: BCM-15006

Event IdTreatmentTreatment SettingAge at StartAge at EndDurationClinical ResponsePathologic ResponseReason Stopped
15Doxorubicin, CyclophosphamideNeoadjuvant33.9534.0744 daysPartial ResponseNot ApplicableTreatment Completed
20Paclitaxel, CarboplatinNeoadjuvant34.1134.3277 daysProgressive DiseaseNot ApplicableTreatment Completed
35Radiation Therapy (RT)Neoadjuvant34.3734.547 daysComplete ResponsePathological Complete Response (pCR)Treatment Completed
40CisplatinNeoadjuvant34.3834.4526 daysComplete ResponsePathological Complete Response (pCR)Treatment Completed
50CapecitabineAdjuvant34.7835.27179 daysNot ReportedNot ApplicableTreatment Completed
65Radiation Therapy (RT)Recurrent/Metastatic35.7835.8526 daysNot ReportedNot ApplicableTreatment Completed
70CapecitabineRecurrent/Metastatic35.835.9244 daysNot ReportedNot ApplicableDisease Progression
75EribulinRecurrent/Metastatic35.9335.93UnknownNot ReportedNot ApplicableDisease Progression














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