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Breast
BCM-0104
Model Details
Patient
PDX Model
Histology
Metastasis
Patient Treatment
Patient Information for Model: BCM-0104
Patient Information
Clinical Timeline
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Clinical Information at Collection
Clinical Biomarkers/Mutations at Collection
Pathology Information at Collection
Model Information for Model: BCM-0104
Biomarkers & Mutations
Model Details
Mutations (Cancer Gene Census List)
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The number of models in this collection with mutations in the listed gene
The number of models in this collection with mutations at the listed site
Total mutations showing: 255
F
P
1
2
3
4
5
6
7
8
9
10
N
E
Rows Per Page
10
15
25
50
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Gene
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Chr
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Start
End
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cDNA Change
Codon Change
Protein Change
TVAF
Gene Mutation Freq.
Site Mutation Freq.
Most Severe Effect
All Effects
Mutation Impact
Transcript ID
ClinVar Clinical Significance
COSMIC ID
gnomAD Non-Cancer AF
dbSNP ID
Gene Mutation Freq.
Site Mutation Freq.
Transcript ID
ClinVar Clinical Significance
COSMIC ID
dbSNP ID
ABI1
chr10
26742285
26742285
A
G
0.799
40
34
Downstream Gene Variant
downstream_gene_variant
MODIFIER
NM_005470.3
rs10764638
40
34
NM_005470.3
rs10764638
ACSL6
chr5
132011827
132011827
G
A
0.947
47
24
Upstream Gene Variant
upstream_gene_variant
MODIFIER
NM_001009185.2
rs4705908
47
24
NM_001009185.2
rs4705908
ACSL6
chr5
132011827
132011827
G
A
0.947
47
24
Intragenic Variant
intragenic_variant
MODIFIER
rs4705908
47
24
rs4705908
AFF1
chr4
87135773
87135773
A
G
0.934
80
80
3' UTR variant
3_prime_UTR_variant
MODIFIER
NM_001166693.2
rs342464
80
80
NM_001166693.2
rs342464
AFF3
chr2
100007213
100007213
C
T
c.497G>A
aGt/aAt
p.Ser166Asn
0.671
10
1
Missense Variant
missense_variant
MODERATE
NM_001025108.1
0.000004220760
rs151087811
10
1
NM_001025108.1
rs151087811
AFF4
chr5
132873544
132873544
G
A
0.906
21
1
Downstream Gene Variant
downstream_gene_variant
MODIFIER
NM_014423.3
rs576657215
21
1
NM_014423.3
rs576657215
AKAP9
chr7
91940976
91940976
G
C
0.97
68
64
5' UTR variant
5_prime_UTR_variant
MODIFIER
NM_005751.4
rs4727267
68
64
NM_005751.4
rs4727267
AR
chrX
67545316
67545316
TGCA
T
c.237_239delGCA
p.Gln80del
0.638
45
8
In-frame Deletion (Disruptive)
disruptive_inframe_deletion
MODERATE
NM_000044.3
rs778920072
45
8
NM_000044.3
rs778920072
ARHGAP26
chr5
143214082
143214082
G
A
c.2350G>A
Gat/Aat
p.Asp784Asn
0.889
3
1
Missense Variant
missense_variant
MODERATE
NM_015071.4
0.000005067700
rs587778049
3
1
NM_015071.4
rs587778049
ARHGEF10L
chr1
17697502
17697503
G
GC
0.958
77
77
3' UTR variant
3_prime_UTR_variant
MODIFIER
NM_018125.3
rs3835471
77
77
NM_018125.3
rs3835471
ATIC
chr2
215311925
215311925
A
G
0.999
79
74
Upstream Gene Variant
upstream_gene_variant
MODIFIER
NM_004044.6
rs78631308
79
74
NM_004044.6
rs78631308
ATIC
chr2
215312084
215312084
T
G
0.998
79
23
5' UTR variant
5_prime_UTR_variant
MODIFIER
NM_004044.6
rs4535042
79
23
NM_004044.6
rs4535042
ATRX
chrX
77682471
77682471
C
G
c.2785G>C
Gag/Cag
p.Glu929Gln
0.563
54
52
Missense Variant
missense_variant
MODERATE
NM_000489.4
rs3088074
54
52
NM_000489.4
rs3088074
B2M
chr15
44711166
44711166
T
G
0.999
48
45
Upstream Gene Variant
upstream_gene_variant
MODIFIER
NM_004048.2
COSN15632065
rs2255235
48
45
NM_004048.2
COSN15632065
rs2255235
BAP1
chr3
52397655
52397655
G
A
0.999
22
8
Downstream Gene Variant
downstream_gene_variant
MODIFIER
NM_004656.3
rs390802
22
8
NM_004656.3
rs390802
Total mutations showing: 255
F
P
1
2
3
4
5
6
7
8
9
10
N
E
Rows Per Page
10
15
25
50
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CNV
Histology Information for Model: BCM-0104
Patient
PDX
H&E
ER
PR
HER2
Metastasis Information for Model: BCM-0104
Patient
PDX
Abdomen
Anterosuperior mediastinum
Bone
Brain
CTC
Chest
Chest wall
Contralateral breast
Fallopian tubes
Hip
Kidney
Leg bone
Liver
Lung
Lymph Node
Mediastinum
Neck
Other
Ovary
Pancreas
Paratracheal adenopathy
Pericardium
Peritoneal cavity
Peritoneum
Pleura
Pleural Cavitiy
Pleural effusion
Posterior cervical nodes
SVC node
Skin
Thymus
Patient Treatment Information for Model: BCM-0104
Event Id
Treatment
Treatment Setting
Age at Start
Age at End
Duration
Clinical Response
Pathologic Response
13
[Paclitaxel]
Neoadjuvant
58.3
58.76
168 days
Partial Response
Not Reported
23
[Radiation Therapy (RT)]
Adjuvant
59.33
59.46
47 days
Not Reported
Not Applicable
33
[Radiation Therapy (RT)]
Recurrent/Metastatic
59.81
59.84
11 days
Not Reported
Not Applicable
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