Model Details

Patient Information for Model: BCM-0104

Patient Information
Clinical Timeline

Color Keys:
 
 Positive
 
 Negative
 
 N/A

Clinical Information at Collection
Clinical Biomarkers/Mutations at Collection
Pathology Information at Collection

Model Information for Model: BCM-0104

Model Details - Initial Implantation of Patient Tissue
Biomarkers & Mutations
Model Details - Acceptable Conditions for Passaging
Mutations (Cancer Gene Census List)

The number of models in this collection with mutations in the listed gene;
may include models that are not publicly available for distribution.
The number of models in this collection with mutations at the listed site;
may include models that are not publicly available for distribution.
GeneChrStartEndRefAltcDNA ChangeCodon ChangeProtein ChangeTVAF Gene Mutation Freq. Site Mutation Freq.Most Severe EffectAll EffectsMutation ImpactTranscript IDClinVar Clinical SignificanceCOSMIC IDgnomAD Non-Cancer AFdbSNP IDGene Mutation Freq.Site Mutation Freq.Transcript IDClinVar Clinical SignificanceCOSMIC IDdbSNP ID
AFF3chr2100007213100007213CTc.497G>AaGt/aAtp.S166N0.671121Missense VariantMissense VariantMODERATEENST00000409579.5


0.000004220760rs151087811
121ENST00000409579.5rs151087811
ARchrX6754531667545319TGCATc.237_239delctGCAg/ctgp.Q80del0.638489In-frame DeletionIn-frame DeletionMODERATEENST00000374690.9

COSV65954886

489ENST00000374690.9COSV65954886
ARHGAP26chr5143214082143214082GAc.2185G>AGat/Aatp.D729N0.88931Missense VariantMissense VariantMODERATEENST00000645722.2
not_provided

0.000005067700rs587778049
31ENST00000645722.2not_providedrs587778049
ARHGEF10chr819285411928541GAc.2812G>AGtt/Attp.V938I0.965102Missense VariantMissense VariantMODERATEENST00000349830.8
Likely_benign
COSV50664968
0.005334550000rs61752020
102ENST00000349830.8Likely_benignCOSV50664968rs61752020
ATRXchrX7768247177682471CGc.2785G>CGag/Cagp.E929Q0.5635956Missense VariantMissense VariantMODERATEENST00000373344.10
Benign

rs3088074
5956ENST00000373344.10Benignrs3088074
CIITAchr161090907010909070AGc.2702A>GcAg/cGgp.Q901R0.9928584Missense VariantMissense VariantMODERATEENST00000618327.4
Benign

0.983235000000rs7197779
8584ENST00000618327.4Benignrs7197779
ERCC2chr194535166145351661TGc.2251A>CAag/Cagp.K751Q0.9524846Missense VariantMissense VariantMODERATEENST00000391945.10
Benign/Likely_benign
COSV67266431
0.322955000000rs13181
4846ENST00000391945.10Benign/Likely_benignCOSV67266431rs13181
ETV5chr3186081073186081073TCc.335A>GtAt/tGtp.Y112C0.52441Missense VariantMissense VariantMODERATEENST00000306376.10


0.000982127000rs61760177
41ENST00000306376.10rs61760177
FOXO3chr6108663973108663973TTGc.1143dup-/Gp.L382Afs*30.1682414Frameshift MutationFrameshift MutationHIGHENST00000406360.2

COSV59629090
rs34133353
2414ENST00000406360.2COSV59629090rs34133353
HOXC11chr125397362553973625CGc.384C>GagC/agGp.S128R0.64231Missense VariantMissense VariantMODERATEENST00000546378.1


0.000285856000rs143575026
31ENST00000546378.1rs143575026
KMT2Cchr7152252613152252613GTc.1402C>ACcc/Accp.P468T0.973521Missense VariantMissense VariantMODERATEENST00000262189.11
not_provided

0.000715005000rs140919432
521ENST00000262189.11not_providedrs140919432
MAML2chr119609221096092219TTGCTGCTGCTc.1812_1820delcaGCAGCAGCAa/caap.Q619_Q621del0.8296859In-frame DeletionIn-frame DeletionMODERATEENST00000524717.6

COSV73262593

6859ENST00000524717.6COSV73262593
MAP3K1chr55688202156882024TCAATc.2845_2847deltCAAca/tcap.T949del0.9064532In-frame DeletionIn-frame DeletionMODERATEENST00000399503.4

COSV68121469

4532ENST00000399503.4COSV68121469
MUC4chr3195791241195791241TTGTCTCCTGCGTAACAc.338_339insTGTTACGCAGGAGACaca/acTGTTACGCAGGAGACap.T113_A114insVTQET0.9688376In-frame InsertionIn-frame InsertionMODERATEENST00000463781.8

COSV62126148
rs71180965
8376ENST00000463781.8COSV62126148rs71180965
MUC4chr3195784872195784968TCCTGTGGATGCTGAGGAAGTGTCGGTGACAAGAAGAGGGATGGCGTGACCTGTGGATGCTGAGGAAGGGCTGGTGACAGGAAGAGGGGTGGCCTGATc.6612_6707delggTCAGGCCACCCCTCTTCCTGTCACCAGCCCTTCCTCAGCATCCACAGGTCACGCCATCCCTCTTCTTGTCACCGACACTTCCTCAGCATCCACAGGa/ggap.P2214_S2245del0.45831In-frame DeletionIn-frame DeletionMODERATEENST00000463781.8


rs1730670340
831ENST00000463781.8rs1730670340
CNV


Histology Information for Model: BCM-0104

Patient

PDX


Metastasis Information for Model: BCM-0104
 
Patient
PDX
Abdomen
Abdominal cavity
Adrenal Gland
Anterosuperior mediastinum
Ascites
Axillary Lymph Node
Bone
Brain
CTC
Chest
Chest wall
Contralateral Breast
Fallopian tubes
Head
Hilar Node
Hip
Kidney
Leg bone
Leptomeninges
Liver
Lung
Lymph Node
Mediastinum
Metastasis Pleura
Neck
None
Other
Ovary
Pancreas
Paratracheal adenopathy
Pericardium
Peritoneal cavity
Peritoneum
Pleura
Pleural cavity
Pleural effusion
Posterior cervical nodes
Pulmonary
Retrocrural Lymph Node
SVC node
Sacral Spine
Skin
Spine
Spleen
Thymus

Patient Treatment Information for Model: BCM-0104

Event IdTreatmentTreatment SettingAge at StartAge at EndDurationClinical ResponsePathologic ResponseReason Stopped
10PaclitaxelNeoadjuvant58.2658.4673 daysPartial ResponseNot ApplicableOther
15PaclitaxelNeoadjuvant58.6758.711 daysProgressive DiseaseNo Response (NR)Disease Progression
25Radiation Therapy (RT)Recurrent/Metastatic59.2959.4247 daysNot ReportedNot ApplicableTreatment Completed
40Radiation Therapy (RT)Recurrent/Metastatic59.9659.96UnknownNot ReportedNot ApplicableDisease Progression














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