Model Details

Patient Information for Model: BCM-0002

Patient Information
Clinical Timeline

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 Positive
 
 Negative
 
 N/A

Clinical Information at Collection
Clinical Biomarkers/Mutations at Collection
Pathology Information at Collection

Model Information for Model: BCM-0002

Model Details - Initial Implantation of Patient Tissue
Biomarkers & Mutations
Model Details - Acceptable Conditions for Passaging
Mutations (Cancer Gene Census List)

The number of models in this collection with mutations in the listed gene;
may include models that are not publicly available for distribution.
The number of models in this collection with mutations at the listed site;
may include models that are not publicly available for distribution.
GeneChrStartEndRefAltcDNA ChangeCodon ChangeProtein ChangeTVAF Gene Mutation Freq. Site Mutation Freq.Most Severe EffectAll EffectsMutation ImpactTranscript IDClinVar Clinical SignificanceCOSMIC IDgnomAD Non-Cancer AFdbSNP IDGene Mutation Freq.Site Mutation Freq.Transcript IDClinVar Clinical SignificanceCOSMIC IDdbSNP ID
AKAP9chr79207772192077721CTc.6791C>TgCc/gTcp.A2264V0.134501Missense VariantMissense VariantMODERATEENST00000356239.8



501ENST00000356239.8
ALKchr22919378129193784GCTCGc.4303_4305delGAG/-p.E1435del0.346102In-frame DeletionIn-frame DeletionMODERATEENST00000389048.8


rs138827116
102ENST00000389048.8rs138827116
ARchrX6754531667545331TGCAGCAGCAGCAGCATc.225_239delctGCAGCAGCAGCAGCAg/ctgp.Q76_Q80del0.706481In-frame DeletionIn-frame DeletionMODERATEENST00000374690.9

COSV104424802

481ENST00000374690.9COSV104424802
ARID1Achr12677569726775697AGc.5114A>GaAc/aGcp.N1705S0.339192Missense VariantMissense VariantMODERATEENST00000324856.13
Benign
COSV104411707
0.006846420000rs61756316
192ENST00000324856.13BenignCOSV104411707rs61756316
ARID1Bchr6156778268156778268CCCAGc.609_611dup-/CAGp.Q214dup0.871372In-frame InsertionIn-frame InsertionMODERATEENST00000636930.2

COSV51651299

372ENST00000636930.2COSV51651299
BCL9chr1147619856147619859CATGCc.1704_1706delATG/-p.M568del0.315112In-frame DeletionIn-frame DeletionMODERATEENST00000234739.8


rs587603499
112ENST00000234739.8rs587603499
CASP9chr11549395315493953GTc.1097C>AaCc/aAcp.T366N0.215137Missense VariantMissense VariantMODERATEENST00000333868.10
Benign
COSV99049509
0.002324200000rs61738967
137ENST00000333868.10BenignCOSV99049509rs61738967
CDH11chr166499880564998805CTc.280G>AGgg/Aggp.G94R0.49361Missense VariantMissense VariantMODERATEENST00000268603.9

COSV51769306

61ENST00000268603.9COSV51769306
CHD2chr159294906392949063CGc.1489C>GCat/Gatp.H497D0.04951Missense VariantMissense VariantMODERATEENST00000394196.9



51ENST00000394196.9
CIITAchr161090907010909070AGc.2702A>GcAg/cGgp.Q901R0.9368584Missense VariantMissense VariantMODERATEENST00000618327.4
Benign

0.983235000000rs7197779
8584ENST00000618327.4Benignrs7197779
CLTCL1chr221922629319226293GAc.1873C>TCaa/Taap.Q625*0.977191Nonsense MutationNonsense MutationHIGHENST00000427926.6


0.000038334100rs372403893
191ENST00000427926.6rs372403893
CNTRLchr9121125866121125866GTc.1955G>TaGa/aTap.R652I0.305101Missense VariantMissense VariantMODERATEENST00000373855.5



101ENST00000373855.5
CREB3L1chr114632073346320733TGc.1547T>GaTc/aGcp.I516S0.5128Missense VariantMissense VariantMODERATEENST00000621158.5
Benign

0.006321900000rs73464035
128ENST00000621158.5Benignrs73464035
CREB3L2chr7137928167137928170CTGGCc.299_301delaCCAgt/agtp.T100del0.9754949In-frame DeletionIn-frame DeletionMODERATEENST00000330387.11

COSV57791862
rs3217268
4949ENST00000330387.11COSV57791862rs3217268
CTNNA2chr28039324580393245TCc.1091T>CaTt/aCtp.I364T0.53174Missense VariantMissense VariantMODERATEENST00000402739.8
Benign
COSV99057397
0.003652210000rs61754542
74ENST00000402739.8BenignCOSV99057397rs61754542
CNV


Histology Information for Model: BCM-0002

Patient

PDX


Metastasis Information for Model: BCM-0002
 
Patient
PDX
Abdomen
Abdominal cavity
Adrenal Gland
Anterosuperior mediastinum
Ascites
Axillary Lymph Node
Bone
Brain
CTC
Chest
Chest wall
Contralateral Breast
Fallopian tubes
Head
Hilar Node
Hip
Kidney
Leg bone
Leptomeninges
Liver
Lung
Lymph Node
Mediastinum
Metastasis Pleura
Neck
None
Other
Ovary
Pancreas
Paratracheal adenopathy
Pericardium
Peritoneal cavity
Peritoneum
Pleura
Pleural cavity
Pleural effusion
Posterior cervical nodes
Pulmonary
Retrocrural Lymph Node
SVC node
Sacral Spine
Skin
Spine
Spleen
Thymus

Patient Treatment Information for Model: BCM-0002

Event IdTreatmentTreatment SettingAge at StartAge at EndDurationClinical ResponsePathologic ResponseReason Stopped
10Docetaxel, DoxorubicinNeoadjuvant43.6244.12183 daysPartial ResponsePartial ResponseCompleted
15Radiation Therapy (RT)Adjuvant43.743.8762 daysNot ReportedNot ApplicableCompleted
20Docetaxel, DoxorubicinAdjuvant43.9544.1262 daysNot ReportedNot ApplicableUnknown
25DocetaxelAdjuvant44.244.62153 daysNot ReportedNot ApplicableUnknown
30TamoxifenAdjuvant45.6250.451763 daysNot ReportedNot ApplicableCompleted
35LetrozoleAdjuvant50.4852.7810 daysNot ReportedNot ApplicableDisease Progression
50Paclitaxel, CarboplatinRecurrent/Metastatic52.7754.12493 daysNot ReportedNot ApplicableUnknown
55CarboplatinRecurrent/Metastatic54.1854.97288 daysNot ReportedNot ApplicableUnknown
60AnastrozoleRecurrent/Metastatic55.6256.08168 daysProgressive DiseaseNot ApplicableDisease Progression
70Radiation Therapy (RT)Recurrent/Metastatic56.0256.129 daysNot ReportedNot ApplicableTreatment Completed
75CapecitabineRecurrent/Metastatic56.0857.02343 daysNot ReportedNot ApplicableDisease Progression
80GemcitabineRecurrent/Metastatic57.0357.91321 daysNot ReportedNot ApplicableDisease Progression
90Radiation Therapy (RT)Recurrent/Metastatic57.1157.11UnknownNot ReportedNot ApplicableTreatment Completed














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